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   HEMOLYTIK: A Database of Hemolytic and Non-hemolytic Peptides

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2701 details
Primary information
Hemolytik ID2701
PMID22328546
YEAR2012
SEQUENCEGIGAVLKVLTTGLPALISWIKRKRQQ
LENGTH26
NAMEMelittin
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryL
Modified ResiduesNone
FUNCTIONCPP
ACTIVITY<60% hemolytic at 25μM at pH 6
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCCSSHHHHHHSCHHHHHHHHHHTTC
SMILESNCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
1bh1A NA NA NA NA NA 20271 NA
Reference Informaiton
ARTICLETruncated peptides from melittin and its analog with high lytic activity at endosomal pH enhance branched polyethylenimine-mediated gene transfection.
AUTHORSTan YX,Chen C,Wang YL,Lin S,Wang Y,Li SB,Jin XP,Gao HW,Du FS,Gong F
JOURNALJ Gene Med. 2012 Apr;14(4):241-50. doi: 10.1002/jgm.2609.