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   HEMOLYTIK: A Database of Hemolytic and Non-hemolytic Peptides

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2643 details
Primary information
Hemolytik ID2643
PMID22837667
YEAR2012
SEQUENCEkWkSFLkTFkSLKkTVLHTLLkAISS
LENGTH26
NAMEK1D/K3D/K7D/K10D/K14D/K22D
C-ter ModificationAmidation
N-ter ModificationAcetylation
Linear/CyclicLinear
StereochemistryMix (Contains both L and D amino acids)
Modified ResiduesNone
FUNCTIONAnticancer
ACTIVITYMHC >325.20μmol/L
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCGGGHHHHHHHTTSHHHHHHHHHCC
SMILESN[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLERole of helicity on the anticancer mechanism of action of cationic-helical peptides.
AUTHORSHuang YB,He LY,Jiang HY
JOURNALInt J Mol Sci. 2012;13(6):6849-62. doi: 10.3390/ijms13066849. Epub 2012 Jun 5.