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2627 details
Primary information
Hemolytik ID2627
PMID22869378
YEAR2012
SEQUENCEkklalalakkwlplakklalalakk
LENGTH25
NAMED-LAK120-AP13
C-ter ModificationAmidation
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryD
Modified ResiduesNone
FUNCTIONAntimicrobial and Antiplasmodial and Anticancer
ACTIVITYHC50 =58.61±10.41μMc
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCHHHHHTGGGGHHHHHHHHHHHHHC
SMILESN[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEConformational flexibility determines selectivity and antibacterial, antiplasmodial, and anticancer potency of cationic ?-helical peptides.
AUTHORSVermeer LS,Lan Y,Abbate V,Ruh E,Bui TT,Wilkinson LJ,Kanno T,Jumagulova E,Kozlowska J,Patel J,McIntyre CA,Yam WC,Siu G,Atkinson RA,Lam JK,Bansal SS, Drake, Alex ,Drake AF,Mitchell GH
JOURNALJ Biol Chem. 2012 Oct 5;287(41):34120-33. doi: 10.1074/jbc.M112.359067. Epub 2012 Aug 6.