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2623 details
Primary information
Hemolytik ID2623
PMID22865764
YEAR2012
SEQUENCEQTRRLTYKpRTVTYTRGR
LENGTH18
NAMEc(1-18) [Gln1,Thr2,6,11,15D-Pro9]-Gm
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryMix (Contains both L and D amino acids)
Modified ResiduesNone
FUNCTIONAntimicrobial
ACTIVITY26.5% hemolytic at 100µM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCTTSSCSSSCCCCCCSCC
SMILESN[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLESynthesis and properties of cyclic gomesin and analogues.
AUTHORSMachado A,Fazio MA,Miranda A,Daffre S
JOURNALJ Pept Sci. 2012 Sep;18(9):588-98. doi: 10.1002/psc.2439. Epub 2012 Aug 2.