Primary information |
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Hemolytik ID | 2557 |
PMID | 10224074 |
YEAR | 1999 |
SEQUENCE | VKLKVyPLKVKLyP |
LENGTH | 14 |
NAME | GS14V1 |
C-ter Modification | Free |
N-ter Modification | Free |
Linear/Cyclic | Cyclic |
Stereochemistry | Mix (Contains both L and D amino acids) |
Modified Residues | None |
FUNCTION | Antimicrobial and Hemolytic |
ACTIVITY | 100% hemolytic at 40μg/ml |
RBCs SOURCE | Human |
Secondary information |
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Properties | Physico-Chemical details |
STRUCTURE | |
DSSP states | CTTCSSCCCCCSCC |
SMILES | N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O |
External Links |
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PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
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Reference Informaiton |
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ARTICLE | Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity. |
AUTHORS | Kondejewski LH,Jelokhani-Niaraki M,Farmer SW,Lix B,Kay CM,Sykes BD,Hancock RE |
JOURNAL | J Biol Chem. 1999 May 7;274(19):13181-92. |