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2506 details
Primary information
Hemolytik ID2506
PMID12931994
YEAR2003
SEQUENCERGGRLCYCRRRFCVCVGR
LENGTH18
NAMEProtegrin-I (2)
C-ter ModificationAmidation
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryL
Modified ResiduesNone
FUNCTIONAntimicrobial
ACTIVITY37% hemolytic at 100μg/ml
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCSCCSCCCCCSCCCCCC
SMILESN[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
1pg1A NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEA family of macrocyclic antibiotics with a mixed peptide-peptoid beta-hairpin backbone conformation.
AUTHORSShankaramma SC,Moehle K,James S,Vrijbloed JW,Obrecht D
JOURNALChem Commun (Camb). 2003 Aug 7;(15):1842-3.