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2486 details
Primary information
Hemolytik ID2486
PMID10799508
YEAR2000
SEQUENCEVKLKVyPLKVKLyP
LENGTH14
NAMEGS14
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryMix (Contains both L and D amino acids)
Modified ResiduesNone
FUNCTIONAntimicrobial and Hemolytic
ACTIVITY100% hemolytic at 10μg/ml
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCTTCSSCCCCCSCC
SMILESN[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEDevelopment of the structural basis for antimicrobial and hemolytic activities of peptides based on gramicidin S and design of novel analogs using NMR spectroscopy.
AUTHORSMcInnes C,Kondejewski LH,Hodges RS
JOURNALJ Biol Chem. 2000 May 12;275(19):14287-94.