Primary information |
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Hemolytik ID | 2476 |
PMID | 12168695 |
YEAR | 2002 |
SEQUENCE | GIGAVLK*VLTTGLpALISWIK*RK*RQQ |
LENGTH | 26 |
NAME | Melittin-A1 |
C-ter Modification | Amidation |
N-ter Modification | Acetylation |
Linear/Cyclic | Linear |
Stereochemistry | Mix (Contains both L and D amino acids) |
Modified Residues | K*: Acetylated Lysin |
FUNCTION | Antibacterial |
ACTIVITY | 50% hemolysis at >200µg/ml |
RBCs SOURCE | Human |
Secondary information |
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Properties | Physico-Chemical details |
STRUCTURE | |
DSSP states | CCCCCTHHHHTCCHHHHHHHHHHHTC |
SMILES | NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O |
External Links |
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PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
1bh1A |
NA |
NA |
NA |
NA |
NA |
20271 |
NA |
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Reference Informaiton |
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ARTICLE | Structure and activity of D-Pro14 melittin. |
AUTHORS | Hewish DR,Barnham KJ,Werkmeister JA,Kirkpatrick A,Bartone N,Liu ST,Norton RS,Curtain C |
JOURNAL | J Protein Chem. 2002 May;21(4):243-53. |