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2472 details
Primary information
Hemolytik ID2472
PMID12168695
YEAR2002
SEQUENCEGIGAVLKVLTTGLpALISWIKRKRQQ
LENGTH26
NAMEMelittin-1
C-ter ModificationAmidation
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryMix (Contains both L and D amino acids)
Modified ResiduesNone
FUNCTIONAntibacterial
ACTIVITY50% hemolysis at >200µg/ml
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCCCCTHHHHTCCHHHHHHHHHHHTC
SMILESNCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
1bh1A NA NA NA NA NA 20271 NA
Reference Informaiton
ARTICLEStructure and activity of D-Pro14 melittin.
AUTHORSHewish DR,Barnham KJ,Werkmeister JA,Kirkpatrick A,Bartone N,Liu ST,Norton RS,Curtain C
JOURNALJ Protein Chem. 2002 May;21(4):243-53.