Primary information |
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Hemolytik ID | 2431 |
PMID | 11682479 |
YEAR | 2002 |
SEQUENCE | VKAkVyPAKVKAyP |
LENGTH | 14 |
NAME | L3/A3 |
C-ter Modification | Free |
N-ter Modification | Free |
Linear/Cyclic | Cyclic |
Stereochemistry | Mix (Contains both L and D amino acids) |
Modified Residues | None |
FUNCTION | Antibacterial and Antifungal |
ACTIVITY | 100% hemolysis at >800µg/ml |
RBCs SOURCE | Human |
Secondary information |
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Properties | Physico-Chemical details |
STRUCTURE | |
DSSP states | CCSSSCSSCCCCCC |
SMILES | N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O |
External Links |
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PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
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Reference Informaiton |
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ARTICLE | Optimization of microbial specificity in cyclic peptides by modulation of hydrophobicity within a defined structural framework. |
AUTHORS | Kondejewski LH,Lee DL,Jelokhani-Niaraki M,Farmer SW,Hancock RE |
JOURNAL | J Biol Chem. 2002 Jan 4;277(1):67-74. Epub 2001 Oct 26. |