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2426 details
Primary information
Hemolytik ID2426
PMID11682479
YEAR2002
SEQUENCELKLkLfPLKLKLfP
LENGTH14
NAMEY2/F2, V3/L3
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryMix (Contains both L and D amino acids)
Modified ResiduesNone
FUNCTIONAntibacterial and Antifungal
ACTIVITY100% hemolysis at 12.5µg/ml
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCTTCCCCTTSCCCC
SMILESN[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEOptimization of microbial specificity in cyclic peptides by modulation of hydrophobicity within a defined structural framework.
AUTHORSKondejewski LH,Lee DL,Jelokhani-Niaraki M,Farmer SW,Hancock RE
JOURNALJ Biol Chem. 2002 Jan 4;277(1):67-74. Epub 2001 Oct 26.