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2274 details
Primary information
Hemolytik ID2274
PMID12404639
YEAR2002
SEQUENCELRLKKRRWKYRV
LENGTH12
NAMEMimetic 4
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryL
Modified ResiduesNone
FUNCTIONAntibacterial
ACTIVITY1% hemolysis at 100µg ml-1
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCSCCSSCCCCC
SMILESN[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEMacrocyclic hairpin mimetics of the cationic antimicrobial peptide protegrin I: a new family of broad-spectrum antibiotics.
AUTHORSShankaramma SC,Athanassiou Z,Zerbe O,Moehle K,Mouton C,Bernardini F,Vrijbloed JW,Obrecht D
JOURNALChembiochem. 2002 Nov 4;3(11):1126-33.