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2005 details
Primary information
Hemolytik ID2005
PMID21928440
YEAR2011
SEQUENCEcgetcvggtcntpgctcswpvctrnglnpv
LENGTH29
NAMED-Kalata B1
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryD
Modified ResiduesNone
FUNCTIONAnticancer and Anti-HIV
ACTIVITYIC50 =77µM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCCSSSSCCCCCTTTTCCCCSSSSSCSCCC
SMILESN[C@@H](CS)C(=O)NCC(=O)N[C@H]1CCC(=O)OOC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]3N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]4N(C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)[C@@H](C)O)CS)C(C)C)[C@@H](C)O)CS)CC(=O)N)[C@@H](C)O)CCC4)CS)[C@@H](C)O)CS)CO)Cc1c[nH]c(C)c1CC)CCC3)C(C)C)CS)[C@@H](C)O)CCCN=C)CC(=O)N)CC(C)C)CC(=O)N)CCC2)C(C)C
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
1nb1A NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEA Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor.
AUTHORSSando L,Henriques ST,Foley F,Simonsen SM,Daly NL,Hall KN,Gustafson KR,Aguilar MI
JOURNALChembiochem. 2011 Nov 4;12(16):2456-62. doi: 10.1002/cbic.201100450. Epub 2011 Sep 16.