Home Page
   HEMOLYTIK: A Database of Hemolytic and Non-hemolytic Peptides

Detailed description page of Hemolytik

This page displays user query in tabular form.

2004 details
Primary information
Hemolytik ID2004
PMID21928440
YEAR2011
SEQUENCECGETCVGGTCNTPGCTCSWPVCTRNGLPV
LENGTH29
NAMEKalata B1
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicCyclic
StereochemistryL
Modified ResiduesNone
FUNCTIONAnticancer and Anti-HIV
ACTIVITYIC50 =26µM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCCGGGTTTSSCCCCCSSSCCCTTCSSCC
SMILESN[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
1nb1A NA NA NA NA NA NA NA
Reference Informaiton
ARTICLEA Synthetic mirror image of kalata B1 reveals that cyclotide activity is independent of a protein receptor.
AUTHORSSando L,Henriques ST,Foley F,Simonsen SM,Daly NL,Hall KN,Gustafson KR,Aguilar MI
JOURNALChembiochem. 2011 Nov 4;12(16):2456-62. doi: 10.1002/cbic.201100450. Epub 2011 Sep 16.