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  HEMOLYTIK: A Database of Hemolytic and Non-hemolytic Peptides

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1897 details
Primary information
Hemolytik ID1897
PMID16142907
YEAR2005
SEQUENCEKWKKLLKKaLKLaKKLLK
LENGTH18
NAMEKLW-L9,13-a
C-ter ModificationAmidation
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryMix (Contains both L and D amino acids)
Modified Residuesa=Nala (Ala-peptoid)
FUNCTIONAntimicrobial
ACTIVITY0% hemolysis at 100µM (non-hemolytic)
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCHHHHHHHHHHHHTTSCC
SMILESN[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLECell selectivity and mechanism of action of antimicrobial model peptides containing peptoid residues.
AUTHORSSong YM,Park Y,Lim SS,Yang ST,Woo ER,Park IS,Lee JS,Kim JI,Hahm KS,Kim Y
JOURNALBiochemistry. 2005 Sep 13;44(36):12094-106.