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   HEMOLYTIK: A Database of Hemolytic and Non-hemolytic Peptides

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1733 details
Primary information
Hemolytik ID1733
PMID17176094
YEAR2006
SEQUENCERGGRLCYCRRRFCVCVGR
LENGTH18
NAMEPG-1
C-ter ModificationAmidation
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryL
Modified ResiduesNone
FUNCTIONAntimicrobial
ACTIVITY~100% hemolysis at above 100µg/ml
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCSCCSCCCCCSCCCCCC
SMILESN[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
1pg1A NA NA NA NA NA NA NA
Reference Informaiton
ARTICLERoles of salt and conformation in the biological and physicochemical behavior of protegrin-1 and designed analogues: correlation of antimicrobial, hemolytic, and lipid bilayer-perturbing activities.
AUTHORSLai JR, Epand, Raquel ,Epand RF,Weisblum B,Epand RM
JOURNALBiochemistry. 2006 Dec 26;45(51):15718-30. Epub 2006 Dec 1.