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   HEMOLYTIK: A Database of Hemolytic and Non-hemolytic Peptides

Detailed description page of Hemolytik

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1455 details
Primary information
Hemolytik ID1455
PMID19703772
YEAR2009
SEQUENCEKLLLKLWLKLLK
LENGTH12
NAMEKL1
C-ter ModificationAmidation
N-ter ModificationAcetylation
Linear/CyclicLinear
StereochemistryL
Modified ResiduesNone
FUNCTIONAntibacterial
ACTIVITY100% hemolysis at >50μg/ml
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCTTHHHHHHHHC
SMILESN[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA NA NA NA NA NA NA
Reference Informaiton
ARTICLESynthesis of antibacterial pseudopeptides with less hemolytic activity from a cytotoxic peptide and their pH-dependent activity.
AUTHORSKim SM,Kim JM,Cho H
JOURNALBioorg Med Chem Lett. 2009 Oct 1;19(19):5627-31. doi: 10.1016/j.bmcl.2009.08.031. Epub 2009 Aug 12.