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   HEMOLYTIK: A Database of Hemolytic and Non-hemolytic Peptides

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1446 details
Primary information
Hemolytik ID1446
PMID19563807
YEAR2009
SEQUENCEGKLIKKFGRKAISYAVKKARGKH
LENGTH23
NAMELtc2a_N-trim
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryL
Modified ResiduesNone
FUNCTIONAntimicrobial and Cytotoxic
ACTIVITYEC50 >36μM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCTTHHHHHHHTTTHHHHTTCCC
SMILESNCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA 2g9pA
from
4
TO
26		 NA Q1ELU1
from
62
TO
84		 NA NA NA NA
Reference Informaiton
ARTICLEN-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins.
AUTHORSPolyansky AA,Vassilevski AA,Volynsky PE,Vorontsova OV,Samsonova OV,Egorova NS,Krylov NA,Feofanov AV,Arseniev AS,Grishin EV
JOURNALFEBS Lett. 2009 Jul 21;583(14):2425-8. doi: 10.1016/j.febslet.2009.06.044. Epub 2009 Jun 27.