| Primary information |
|---|
| Hemolytik ID | 1287 |
| PMID | 19132829 |
| YEAR | 2009 |
| SEQUENCE | VOL-dip-PVOL-dip-P |
| LENGTH | 10 |
| NAME | GS4 |
| C-ter Modification | Free |
| N-ter Modification | Free |
| Linear/Cyclic | Cyclic |
| Stereochemistry | Mix (Contains both L and D amino acids) |
| Modified Residues | Ornithine, Dip= β, β-diphenylalanine |
| FUNCTION | Antimicrobial |
| ACTIVITY | HC50=8.6(±1.1)μM |
| RBCs SOURCE | Sheep |
| Secondary information |
|---|
| Properties | Physico-Chemical details |
| STRUCTURE | |
| DSSP states | NA |
| SMILES | NA |
| External Links |
|---|
| PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
| NA |
NA |
NA |
NA |
NA |
NA |
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|
| Reference Informaiton |
|---|
| ARTICLE | Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at the beta-turn. |
| AUTHORS | Solanas C,de la Torre BG,Fernandez-Reyes M,Santiveri CM,Jimenez MA,Rivas L,Jimenez AI,Andreu D |
| JOURNAL | J Med Chem. 2009 Feb 12;52(3):664-74. doi: 10.1021/jm800886n. |
