Primary information |
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Hemolytik ID | 1284 |
PMID | 19132829 |
YEAR | 2009 |
SEQUENCE | VOL-hpa-PVOL-hpa-P |
LENGTH | 10 |
NAME | GS1 |
C-ter Modification | Free |
N-ter Modification | Free |
Linear/Cyclic | Cyclic |
Stereochemistry | Mix (Contains both L and D amino acids) |
Modified Residues | Ornithine, Hpa= homophenylalanine |
FUNCTION | Antimicrobial |
ACTIVITY | HC50=7.0(±0.3)μM |
RBCs SOURCE | Sheep |
Secondary information |
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Properties | Physico-Chemical details |
STRUCTURE | |
DSSP states | NA |
SMILES | NA |
External Links |
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PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
NA |
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Reference Informaiton |
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ARTICLE | Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at the beta-turn. |
AUTHORS | Solanas C,de la Torre BG,Fernandez-Reyes M,Santiveri CM,Jimenez MA,Rivas L,Jimenez AI,Andreu D |
JOURNAL | J Med Chem. 2009 Feb 12;52(3):664-74. doi: 10.1021/jm800886n. |