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   HEMOLYTIK: A Database of Hemolytic and Non-hemolytic Peptides

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1275 details
Primary information
Hemolytik ID1275
PMID20033827
YEAR2011
SEQUENCEFWGALAKGALKLIPSLFSSFSKKD
LENGTH24
NAMEPin2
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicLinear
StereochemistryL
Modified ResiduesNone
FUNCTIONAntimicrobial
ACTIVITYIC50 =3.3μM
RBCs SOURCEHuman
Secondary information
PropertiesPhysico-Chemical details
STRUCTURE
Natural StructureFinal Structure
DSSP statesCCTTSCCSGGGSHHHHHHHHTTCC
SMILESN[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NA NA P83240 NA NA NA NA NA
Reference Informaiton
ARTICLEAmino acid substitutions in an alpha-helical antimicrobial arachnid peptide affect its chemical properties and biological activity towards pathogenic bacteria but improves its therapeutic index.
AUTHORSRodriguez A,Villegas E,Satake H,Possani LD
JOURNALAmino Acids. 2011 Jan;40(1):61-8. doi: 10.1007/s00726-009-0449-y. Epub 2009 Dec 24.