Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
CTNNB1	APLSGKGNP	SKIN	43	p.S45del	c.131_133delCTT	In_Frame_Del	2	0.22	COLO783	N	0	0	0	N
CTNNB1	APLSGKGNP	LARGE_INTESTINE	43	p.S45del	c.131_133delCTT	In_Frame_Del	2	0.22	HCT116	N	0	0	0	N
CTNNB1	ATTTAPLSG	SKIN	39	p.S45del	c.131_133delCTT	In_Frame_Del	3	0.22	COLO783	N	0	0	0	N
CTNNB1	ATTTAPLSG	LARGE_INTESTINE	39	p.S45del	c.131_133delCTT	In_Frame_Del	3	0.22	HCT116	N	0	0	0	N
CTNNB1	GATTTAPLS	SKIN	38	p.S45del	c.131_133delCTT	In_Frame_Del	2	0.22	COLO783	N	1	0	0	N
CTNNB1	GATTTAPLS	LARGE_INTESTINE	38	p.S45del	c.131_133delCTT	In_Frame_Del	2	0.22	HCT116	N	1	0	0	N
CTNNB1	SGATTTAPL	SKIN	37	p.S45del	c.131_133delCTT	In_Frame_Del	1	0.22	COLO783	N	10	0	0	N
CTNNB1	SGATTTAPL	LARGE_INTESTINE	37	p.S45del	c.131_133delCTT	In_Frame_Del	1	0.22	HCT116	N	10	0	0	N
CTNNB1	TAPLSGKGN	SKIN	42	p.S45del	c.131_133delCTT	In_Frame_Del	3	0.22	COLO783	N	1	0	0	N
CTNNB1	TAPLSGKGN	LARGE_INTESTINE	42	p.S45del	c.131_133delCTT	In_Frame_Del	3	0.22	HCT116	N	1	0	0	N
CTNNB1	TTAPLSGKG	SKIN	41	p.S45del	c.131_133delCTT	In_Frame_Del	3	0.22	COLO783	N	0	0	0	N
CTNNB1	TTAPLSGKG	LARGE_INTESTINE	41	p.S45del	c.131_133delCTT	In_Frame_Del	3	0.22	HCT116	N	0	0	0	N
CTNNB1	TTTAPLSGK	SKIN	40	p.S45del	c.131_133delCTT	In_Frame_Del	3	0.22	COLO783	N	2	0	0	N
CTNNB1	TTTAPLSGK	LARGE_INTESTINE	40	p.S45del	c.131_133delCTT	In_Frame_Del	3	0.22	HCT116	N	2	0	0	N
CTNNB1	PLSGKGNPE	SKIN	44	p.S45del	c.131_133delCTT	In_Frame_Del	1	0.33	COLO783	N	0	0	0	N
CTNNB1	PLSGKGNPE	LARGE_INTESTINE	44	p.S45del	c.131_133delCTT	In_Frame_Del	1	0.33	HCT116	N	0	0	0	N