Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CDH1 | AEKRVEVSE | STOMACH | 483 | p.PIFVPP484del | c.1448_1465delCCCCCATCTTTGTGCCTC | In_Frame_Del | 1 | 0.11 | NCCSTCK140 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | CPFPKNLVQ | LUNG | 163 | p.PENEKG164del | c.488_505delGCCCAGAAAATGAAAAAG | In_Frame_Del | 1 | 0.11 | NCIH2122 | N | 1 | 0 | 0 | N | ||||||||||||
| CDH1 | DVLDVNEAE | STOMACH | 476 | p.PIFVPP484del | c.1448_1465delCCCCCATCTTTGTGCCTC | In_Frame_Del | 1 | 0.11 | NCCSTCK140 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | DVNEAEKRV | STOMACH | 479 | p.PIFVPP484del | c.1448_1465delCCCCCATCTTTGTGCCTC | In_Frame_Del | 3 | 0.11 | NCCSTCK140 | N | 4 | 0 | 0 | N | ||||||||||||
| CDH1 | EAEKRVEVS | STOMACH | 482 | p.PIFVPP484del | c.1448_1465delCCCCCATCTTTGTGCCTC | In_Frame_Del | 2 | 0.11 | NCCSTCK140 | N | 2 | 0 | 0 | N | ||||||||||||
| CDH1 | IPPISCPFP | LUNG | 158 | p.PENEKG164del | c.488_505delGCCCAGAAAATGAAAAAG | In_Frame_Del | 2 | 0.11 | NCIH2122 | N | 1 | 0 | 0 | N | ||||||||||||
| CDH1 | ISCPFPKNL | LUNG | 161 | p.PENEKG164del | c.488_505delGCCCAGAAAATGAAAAAG | In_Frame_Del | 3 | 0.11 | NCIH2122 | Y | 11 | 10 | 0 | N | ||||||||||||
| CDH1 | LDVNEAEKR | STOMACH | 478 | p.PIFVPP484del | c.1448_1465delCCCCCATCTTTGTGCCTC | In_Frame_Del | 3 | 0.11 | NCCSTCK140 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | NEAEKRVEV | STOMACH | 481 | p.PIFVPP484del | c.1448_1465delCCCCCATCTTTGTGCCTC | In_Frame_Del | 3 | 0.11 | NCCSTCK140 | Y | 8 | 12 | 0 | N | ||||||||||||
| CDH1 | PISCPFPKN | LUNG | 160 | p.PENEKG164del | c.488_505delGCCCAGAAAATGAAAAAG | In_Frame_Del | 4 | 0.11 | NCIH2122 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | PPISCPFPK | LUNG | 159 | p.PENEKG164del | c.488_505delGCCCAGAAAATGAAAAAG | In_Frame_Del | 3 | 0.11 | NCIH2122 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | SCPFPKNLV | LUNG | 162 | p.PENEKG164del | c.488_505delGCCCAGAAAATGAAAAAG | In_Frame_Del | 2 | 0.11 | NCIH2122 | N | 0 | 0 | 0 | N | ||||||||||||
| CDH1 | VIPPISCPF | LUNG | 157 | p.PENEKG164del | c.488_505delGCCCAGAAAATGAAAAAG | In_Frame_Del | 1 | 0.11 | NCIH2122 | N | 7 | 0 | 0 | N | ||||||||||||
| CDH1 | VLDVNEAEK | STOMACH | 477 | p.PIFVPP484del | c.1448_1465delCCCCCATCTTTGTGCCTC | In_Frame_Del | 2 | 0.11 | NCCSTCK140 | Y | 5 | 14 | 0 | N | ||||||||||||
| CDH1 | VNEAEKRVE | STOMACH | 480 | p.PIFVPP484del | c.1448_1465delCCCCCATCTTTGTGCCTC | In_Frame_Del | 4 | 0.11 | NCCSTCK140 | N | 0 | 0 | 1 | N | ||||||||||||
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