Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
AKAP12	AGQETEKGE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1590	p.E1597del	c.4787_4789delAAG	In_Frame_Del	2	0.11	KG1	N	0	0	0	N
AKAP12	DAGQETEKG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1589	p.E1597del	c.4787_4789delAAG	In_Frame_Del	1	0.11	KG1	N	0	0	0	N
AKAP12	EKGEEPQAS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1595	p.E1597del	c.4787_4789delAAG	In_Frame_Del	2	0.11	KG1	N	1	0	0	N
AKAP12	ETEKGEEPQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1593	p.E1597del	c.4787_4789delAAG	In_Frame_Del	4	0.11	KG1	N	0	0	0	N
AKAP12	GQETEKGEE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1591	p.E1597del	c.4787_4789delAAG	In_Frame_Del	2	0.11	KG1	N	0	0	0	N
AKAP12	KGEEPQASA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1596	p.E1597del	c.4787_4789delAAG	In_Frame_Del	1	0.11	KG1	N	2	0	0	N
AKAP12	QETEKGEEP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1592	p.E1597del	c.4787_4789delAAG	In_Frame_Del	3	0.11	KG1	N	0	0	0	N
AKAP12	TEKGEEPQA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	1594	p.E1597del	c.4787_4789delAAG	In_Frame_Del	3	0.11	KG1	N	5	0	0	N
AKAP12	ALNSQEEEV	AUTONOMIC_GANGLIA	93	p.E101del	c.295_297delGAA	In_Frame_Del	1	0.33	IMR32	Y	3	12	0	N
AKAP12	ALNSQEEEV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	93	p.E101del	c.295_297delGAA	In_Frame_Del	1	0.33	JM1	Y	3	12	0	N
AKAP12	ALNSQEEEV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	93	p.E101del	c.295_297delGAA	In_Frame_Del	1	0.33	M07E	Y	3	12	0	N
AKAP12	LNSQEEEVI	AUTONOMIC_GANGLIA	94	p.E101del	c.295_297delGAA	In_Frame_Del	2	0.33	IMR32	N	4	0	0	N
AKAP12	LNSQEEEVI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	94	p.E101del	c.295_297delGAA	In_Frame_Del	2	0.33	JM1	N	4	0	0	N
AKAP12	LNSQEEEVI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	94	p.E101del	c.295_297delGAA	In_Frame_Del	2	0.33	M07E	N	4	0	0	N
AKAP12	NSQEEEVIV	AUTONOMIC_GANGLIA	95	p.E101del	c.295_297delGAA	In_Frame_Del	3	0.33	IMR32	N	4	0	0	N
AKAP12	NSQEEEVIV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	95	p.E101del	c.295_297delGAA	In_Frame_Del	3	0.33	JM1	N	4	0	0	N
AKAP12	NSQEEEVIV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	95	p.E101del	c.295_297delGAA	In_Frame_Del	3	0.33	M07E	N	4	0	0	N
AKAP12	QEEEVIVTE	AUTONOMIC_GANGLIA	97	p.E101del	c.295_297delGAA	In_Frame_Del	1	0.33	IMR32	N	0	0	0	N
AKAP12	QEEEVIVTE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	97	p.E101del	c.295_297delGAA	In_Frame_Del	1	0.33	JM1	N	0	0	0	N
AKAP12	QEEEVIVTE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	97	p.E101del	c.295_297delGAA	In_Frame_Del	1	0.33	M07E	N	0	0	0	N
AKAP12	SQEEEVIVT	AUTONOMIC_GANGLIA	96	p.E101del	c.295_297delGAA	In_Frame_Del	2	0.33	IMR32	N	4	0	0	N
AKAP12	SQEEEVIVT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	96	p.E101del	c.295_297delGAA	In_Frame_Del	2	0.33	JM1	N	4	0	0	N
AKAP12	SQEEEVIVT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	96	p.E101del	c.295_297delGAA	In_Frame_Del	2	0.33	M07E	N	4	0	0	N
AKAP12	AVEECKEEE	OVARY	261	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	CAOV3	N	0	0	0	N
AKAP12	AVEECKEEE	LUNG	261	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	HLFA	N	0	0	0	N
AKAP12	AVEECKEEE	SKIN	261	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	IPC298	N	0	0	0	N
AKAP12	AVEECKEEE	PROSTATE	261	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	MDAPCA2B	N	0	0	0	N
AKAP12	AVEECKEEE	LUNG	261	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	NCIH2110	N	0	0	0	N
AKAP12	AVEECKEEE	LUNG	261	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	NCIH23	N	0	0	0	N
AKAP12	AVEECKEEE	OESOPHAGUS	261	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	OE19	N	0	0	0	N
AKAP12	AVEECKEEE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	261	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	RAJI	N	0	0	0	N
AKAP12	CKEEEEKQE	OVARY	265	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	CAOV3	N	0	0	0	Y
AKAP12	CKEEEEKQE	LUNG	265	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	HLFA	N	0	0	0	Y
AKAP12	CKEEEEKQE	SKIN	265	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	IPC298	N	0	0	0	Y
AKAP12	CKEEEEKQE	PROSTATE	265	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	MDAPCA2B	N	0	0	0	Y
AKAP12	CKEEEEKQE	LUNG	265	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	NCIH2110	N	0	0	0	Y
AKAP12	CKEEEEKQE	LUNG	265	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	NCIH23	N	0	0	0	Y
AKAP12	CKEEEEKQE	OESOPHAGUS	265	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	OE19	N	0	0	0	Y
AKAP12	CKEEEEKQE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	265	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	RAJI	N	0	0	0	Y
AKAP12	ECKEEEEKQ	OVARY	264	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	CAOV3	N	0	0	0	N
AKAP12	ECKEEEEKQ	LUNG	264	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	HLFA	N	0	0	0	N
AKAP12	ECKEEEEKQ	SKIN	264	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	IPC298	N	0	0	0	N
AKAP12	ECKEEEEKQ	PROSTATE	264	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	MDAPCA2B	N	0	0	0	N
AKAP12	ECKEEEEKQ	LUNG	264	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	NCIH2110	N	0	0	0	N
AKAP12	ECKEEEEKQ	LUNG	264	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	NCIH23	N	0	0	0	N
AKAP12	ECKEEEEKQ	OESOPHAGUS	264	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	OE19	N	0	0	0	N
AKAP12	ECKEEEEKQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	264	p.G269del	c.804_806delAGG	In_Frame_Del	3	0.88	RAJI	N	0	0	0	N
AKAP12	EECKEEEEK	OVARY	263	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	CAOV3	N	0	0	0	N
AKAP12	EECKEEEEK	LUNG	263	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	HLFA	N	0	0	0	N
AKAP12	EECKEEEEK	SKIN	263	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	IPC298	N	0	0	0	N
AKAP12	EECKEEEEK	PROSTATE	263	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	MDAPCA2B	N	0	0	0	N
AKAP12	EECKEEEEK	LUNG	263	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	NCIH2110	N	0	0	0	N
AKAP12	EECKEEEEK	LUNG	263	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	NCIH23	N	0	0	0	N
AKAP12	EECKEEEEK	OESOPHAGUS	263	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	OE19	N	0	0	0	N
AKAP12	EECKEEEEK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	263	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	RAJI	N	0	0	0	N
AKAP12	EEEEKQEKE	OVARY	267	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	CAOV3	N	0	0	0	N
AKAP12	EEEEKQEKE	LUNG	267	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	HLFA	N	0	0	0	N
AKAP12	EEEEKQEKE	SKIN	267	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	IPC298	N	0	0	0	N
AKAP12	EEEEKQEKE	PROSTATE	267	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	MDAPCA2B	N	0	0	0	N
AKAP12	EEEEKQEKE	LUNG	267	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	NCIH2110	N	0	0	0	N
AKAP12	EEEEKQEKE	LUNG	267	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	NCIH23	N	0	0	0	N
AKAP12	EEEEKQEKE	OESOPHAGUS	267	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	OE19	N	0	0	0	N
AKAP12	EEEEKQEKE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	267	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	RAJI	N	0	0	0	N
AKAP12	EEEKQEKEP	OVARY	268	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	CAOV3	N	0	0	0	N
AKAP12	EEEKQEKEP	LUNG	268	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	HLFA	N	0	0	0	N
AKAP12	EEEKQEKEP	SKIN	268	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	IPC298	N	0	0	0	N
AKAP12	EEEKQEKEP	PROSTATE	268	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	MDAPCA2B	N	0	0	0	N
AKAP12	EEEKQEKEP	LUNG	268	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	NCIH2110	N	0	0	0	N
AKAP12	EEEKQEKEP	LUNG	268	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	NCIH23	N	0	0	0	N
AKAP12	EEEKQEKEP	OESOPHAGUS	268	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	OE19	N	0	0	0	N
AKAP12	EEEKQEKEP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	268	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	RAJI	N	0	0	0	N
AKAP12	KEEEEKQEK	OVARY	266	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	CAOV3	N	3	0	0	N
AKAP12	KEEEEKQEK	LUNG	266	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	HLFA	N	3	0	0	N
AKAP12	KEEEEKQEK	SKIN	266	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	IPC298	N	3	0	0	N
AKAP12	KEEEEKQEK	PROSTATE	266	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	MDAPCA2B	N	3	0	0	N
AKAP12	KEEEEKQEK	LUNG	266	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	NCIH2110	N	3	0	0	N
AKAP12	KEEEEKQEK	LUNG	266	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	NCIH23	N	3	0	0	N
AKAP12	KEEEEKQEK	OESOPHAGUS	266	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	OE19	N	3	0	0	N
AKAP12	KEEEEKQEK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	266	p.G269del	c.804_806delAGG	In_Frame_Del	2	0.88	RAJI	N	3	0	0	N
AKAP12	VEECKEEEE	OVARY	262	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	CAOV3	N	0	0	0	N
AKAP12	VEECKEEEE	LUNG	262	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	HLFA	N	0	0	0	N
AKAP12	VEECKEEEE	SKIN	262	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	IPC298	N	0	0	0	N
AKAP12	VEECKEEEE	PROSTATE	262	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	MDAPCA2B	N	0	0	0	N
AKAP12	VEECKEEEE	LUNG	262	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	NCIH2110	N	0	0	0	N
AKAP12	VEECKEEEE	LUNG	262	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	NCIH23	N	0	0	0	N
AKAP12	VEECKEEEE	OESOPHAGUS	262	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	OE19	N	0	0	0	N
AKAP12	VEECKEEEE	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	262	p.G269del	c.804_806delAGG	In_Frame_Del	1	0.88	RAJI	N	0	0	0	N