Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PTEN | TLYQDQRKP | BREAST | 277 | p.F278fs | c.834_837delCTTC | Frame_Shift_Del | 7 | 0.11 | CAMA1 | N | 0 | 0 | 0 | N | ||||||||||||
| PTEN | CYGISCRKT | STOMACH | 34 | p.R11fs | c.32_33insA | Frame_Shift_Ins | 7 | 0.11 | SH10TC | N | 1 | 0 | 0 | N | ||||||||||||
| PTEN | GRPNWCNDM | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 129 | p.G129fs | c.387_388insCGCC | Frame_Shift_Ins | 7 | 0.11 | U937 | Y | 3 | 9 | 0 | N | ||||||||||||
| PTEN | RPNWCNDMC | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 130 | p.G129fs | c.387_388insCGCC | Frame_Shift_Ins | 7 | 0.11 | U937 | N | 5 | 0 | 0 | N | ||||||||||||
| PTEN | SGQIFKGTR | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 143 | p.G129fs | c.387_388insCGCC | Frame_Shift_Ins | 7 | 0.11 | U937 | N | 1 | 0 | 0 | N | ||||||||||||
| PTEN | TATGRQVHV | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 232 | p.T232fs | c.696_697insG | Frame_Shift_Ins | 7 | 0.11 | P31FUJ | N | 5 | 0 | 0 | N | ||||||||||||
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