Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| NR1H2 | APLSLAPLL | LARGE_INTESTINE | 17 | p.T11fs | c.32_32delC | Frame_Shift_Del | 5 | 0.11 | KM12 | Y | 25 | 10 | 0 | N | ||||||||||||
| NR1H2 | CLEMAPLSL | LARGE_INTESTINE | 13 | p.T11fs | c.32_32delC | Frame_Shift_Del | 6 | 0.11 | KM12 | N | 8 | 0 | 0 | N | ||||||||||||
| NR1H2 | DTPCLEMAP | LARGE_INTESTINE | 10 | p.T11fs | c.32_32delC | Frame_Shift_Del | 5 | 0.11 | KM12 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | EMAPLSLAP | LARGE_INTESTINE | 15 | p.T11fs | c.32_32delC | Frame_Shift_Del | 6 | 0.11 | KM12 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | LAPLLLHPL | LARGE_INTESTINE | 21 | p.T11fs | c.32_32delC | Frame_Shift_Del | 5 | 0.11 | KM12 | N | 21 | 0 | 0 | N | ||||||||||||
| NR1H2 | LDTPCLEMA | LARGE_INTESTINE | 9 | p.T11fs | c.32_32delC | Frame_Shift_Del | 5 | 0.11 | KM12 | N | 5 | 0 | 0 | N | ||||||||||||
| NR1H2 | LEMAPLSLA | LARGE_INTESTINE | 14 | p.T11fs | c.32_32delC | Frame_Shift_Del | 6 | 0.11 | KM12 | N | 8 | 0 | 0 | N | ||||||||||||
| NR1H2 | LSLAPLLLH | LARGE_INTESTINE | 19 | p.T11fs | c.32_32delC | Frame_Shift_Del | 5 | 0.11 | KM12 | N | 0 | 0 | 6 | N | ||||||||||||
| NR1H2 | MAPLSLAPL | LARGE_INTESTINE | 16 | p.T11fs | c.32_32delC | Frame_Shift_Del | 5 | 0.11 | KM12 | N | 17 | 0 | 0 | N | ||||||||||||
| NR1H2 | PCLEMAPLS | LARGE_INTESTINE | 12 | p.T11fs | c.32_32delC | Frame_Shift_Del | 5 | 0.11 | KM12 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | PLSLAPLLL | LARGE_INTESTINE | 18 | p.T11fs | c.32_32delC | Frame_Shift_Del | 5 | 0.11 | KM12 | N | 2 | 0 | 0 | N | ||||||||||||
| NR1H2 | SLAPLLLHP | LARGE_INTESTINE | 20 | p.T11fs | c.32_32delC | Frame_Shift_Del | 5 | 0.11 | KM12 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | SLDTPCLEM | LARGE_INTESTINE | 8 | p.T11fs | c.32_32delC | Frame_Shift_Del | 4 | 0.11 | KM12 | Y | 3 | 9 | 0 | N | ||||||||||||
| NR1H2 | TPCLEMAPL | LARGE_INTESTINE | 11 | p.T11fs | c.32_32delC | Frame_Shift_Del | 6 | 0.11 | KM12 | Y | 14 | 10 | 0 | N | ||||||||||||
| NR1H2 | ADPPVPRCP | ENDOMETRIUM | 256 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 0 | 0 | 0 | Y | ||||||||||||
| NR1H2 | AGHHLSPGD | ENDOMETRIUM | 274 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | ATLCPLHGA | ENDOMETRIUM | 266 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | N | 2 | 0 | 0 | N | ||||||||||||
| NR1H2 | CPLHGAGHH | ENDOMETRIUM | 269 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | CPPATLCPL | ENDOMETRIUM | 263 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 20 | 0 | 0 | N | ||||||||||||
| NR1H2 | DPPVPRCPP | ENDOMETRIUM | 257 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 1 | 0 | 0 | N | ||||||||||||
| NR1H2 | GADPPVPRC | ENDOMETRIUM | 255 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 4 | 0.11 | HEC59 | Y | 3 | 9 | 0 | N | ||||||||||||
| NR1H2 | GAGHHLSPG | ENDOMETRIUM | 273 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | GHHLSPGDR | ENDOMETRIUM | 275 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 1 | 0 | 0 | N | ||||||||||||
| NR1H2 | HGAGHHLSP | ENDOMETRIUM | 272 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | HHLSPGDRG | ENDOMETRIUM | 276 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | HLSPGDRGL | ENDOMETRIUM | 277 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | Y | 5 | 10 | 0 | N | ||||||||||||
| NR1H2 | LCPLHGAGH | ENDOMETRIUM | 268 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | LGADPPVPR | ENDOMETRIUM | 254 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 4 | 0.11 | HEC59 | N | 1 | 0 | 7 | N | ||||||||||||
| NR1H2 | LHGAGHHLS | ENDOMETRIUM | 271 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | N | 1 | 0 | 3 | N | ||||||||||||
| NR1H2 | LSPGDRGLR | ENDOMETRIUM | 278 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | N | 3 | 0 | 0 | Y | ||||||||||||
| NR1H2 | PATLCPLHG | ENDOMETRIUM | 265 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | PLHGAGHHL | ENDOMETRIUM | 270 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 2 | 0 | 0 | N | ||||||||||||
| NR1H2 | PPATLCPLH | ENDOMETRIUM | 264 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | PPVPRCPPA | ENDOMETRIUM | 258 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 4 | 0 | 0 | N | ||||||||||||
| NR1H2 | PRCPPATLC | ENDOMETRIUM | 261 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | N | 1 | 0 | 0 | N | ||||||||||||
| NR1H2 | PVPRCPPAT | ENDOMETRIUM | 259 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | RCPPATLCP | ENDOMETRIUM | 262 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | TLCPLHGAG | ENDOMETRIUM | 267 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 5 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| NR1H2 | VPRCPPATL | ENDOMETRIUM | 260 | p.D257fs | c.770_771insC | Frame_Shift_Ins | 6 | 0.11 | HEC59 | Y | 14 | 11 | 0 | N | ||||||||||||
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