Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MSH6 | AVLMFYCAW | URINARY_TRACT | 1055 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 6 | 0.11 | 639V | Y | 1 | 9 | 0 | N | ||||||||||||
| MSH6 | AWLTIVEGV | URINARY_TRACT | 1062 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 6 | 0.11 | 639V | N | 4 | 0 | 0 | N | ||||||||||||
| MSH6 | CAWLTIVEG | URINARY_TRACT | 1061 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 6 | 0.11 | 639V | N | 0 | 0 | 0 | N | ||||||||||||
| MSH6 | CIAVLMFYC | URINARY_TRACT | 1053 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 4 | 0.11 | 639V | Y | 1 | 9 | 0 | N | ||||||||||||
| MSH6 | ECIAVLMFY | URINARY_TRACT | 1052 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 3 | 0.11 | 639V | N | 7 | 0 | 0 | N | ||||||||||||
| MSH6 | EGVMVLCVA | URINARY_TRACT | 1068 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 5 | 0.11 | 639V | N | 2 | 0 | 0 | N | ||||||||||||
| MSH6 | FYCAWLTIV | URINARY_TRACT | 1059 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 5 | 0.11 | 639V | Y | 7 | 9 | 0 | N | ||||||||||||
| MSH6 | GVMVLCVAQ | URINARY_TRACT | 1069 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 5 | 0.11 | 639V | N | 0 | 0 | 0 | N | ||||||||||||
| MSH6 | IAVLMFYCA | URINARY_TRACT | 1054 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 5 | 0.11 | 639V | N | 9 | 0 | 0 | N | ||||||||||||
| MSH6 | IVEGVMVLC | URINARY_TRACT | 1066 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 5 | 0.11 | 639V | N | 1 | 0 | 0 | N | ||||||||||||
| MSH6 | LMFYCAWLT | URINARY_TRACT | 1057 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 6 | 0.11 | 639V | N | 7 | 0 | 5 | N | ||||||||||||
| MSH6 | LTIVEGVMV | URINARY_TRACT | 1064 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 5 | 0.11 | 639V | N | 6 | 0 | 4 | N | ||||||||||||
| MSH6 | MFYCAWLTI | URINARY_TRACT | 1058 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 5 | 0.11 | 639V | Y | 12 | 10 | 4 | N | ||||||||||||
| MSH6 | TIVEGVMVL | URINARY_TRACT | 1065 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 5 | 0.11 | 639V | Y | 16 | 10 | 0 | N | ||||||||||||
| MSH6 | VECIAVLMF | URINARY_TRACT | 1051 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 2 | 0.11 | 639V | Y | 8 | 11 | 10 | N | ||||||||||||
| MSH6 | VEGVMVLCV | URINARY_TRACT | 1067 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 4 | 0.11 | 639V | N | 10 | 0 | 8 | N | ||||||||||||
| MSH6 | VLMFYCAWL | URINARY_TRACT | 1056 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 6 | 0.11 | 639V | N | 13 | 0 | 25 | N | ||||||||||||
| MSH6 | WLTIVEGVM | URINARY_TRACT | 1063 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 5 | 0.11 | 639V | N | 6 | 0 | 0 | N | ||||||||||||
| MSH6 | YCAWLTIVE | URINARY_TRACT | 1060 | p.L1057fs | c.3171_3171delG | Frame_Shift_Del | 5 | 0.11 | 639V | N | 2 | 0 | 3 | N | ||||||||||||
| MSH6 | DKNYKTGSL | THYROID | 1041 | p.K1045fs | c.3135_3135delG | Frame_Shift_Del | 4 | 0.22 | FTC133 | N | 5 | 0 | 0 | N | ||||||||||||
| MSH6 | DKNYKTGSL | THYROID | 1041 | p.K1045fs | c.3135_3135delG | Frame_Shift_Del | 4 | 0.22 | FTC238 | N | 5 | 0 | 0 | N | ||||||||||||
| MSH6 | FDKNYKTGS | THYROID | 1040 | p.K1045fs | c.3135_3135delG | Frame_Shift_Del | 3 | 0.22 | FTC133 | N | 4 | 0 | 0 | N | ||||||||||||
| MSH6 | FDKNYKTGS | THYROID | 1040 | p.K1045fs | c.3135_3135delG | Frame_Shift_Del | 3 | 0.22 | FTC238 | N | 4 | 0 | 0 | N | ||||||||||||
| MSH6 | KNYKTGSLL | THYROID | 1042 | p.K1045fs | c.3135_3135delG | Frame_Shift_Del | 5 | 0.22 | FTC133 | N | 15 | 0 | 0 | N | ||||||||||||
| MSH6 | KNYKTGSLL | THYROID | 1042 | p.K1045fs | c.3135_3135delG | Frame_Shift_Del | 5 | 0.22 | FTC238 | N | 15 | 0 | 0 | N | ||||||||||||
| MSH6 | NFDKNYKTG | THYROID | 1039 | p.K1045fs | c.3135_3135delG | Frame_Shift_Del | 2 | 0.22 | FTC133 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH6 | NFDKNYKTG | THYROID | 1039 | p.K1045fs | c.3135_3135delG | Frame_Shift_Del | 2 | 0.22 | FTC238 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH6 | EDTPPLLRA | THYROID | 1083 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 3 | 1.11 | FTC238 | N | 4 | 0 | 0 | Y | ||||||||||||
| MSH6 | EDTPPLLRA | LARGE_INTESTINE | 1083 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 3 | 1.11 | GP2D | N | 4 | 0 | 0 | Y | ||||||||||||
| MSH6 | EDTPPLLRA | ENDOMETRIUM | 1083 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 3 | 1.11 | HEC151 | N | 4 | 0 | 0 | Y | ||||||||||||
| MSH6 | EDTPPLLRA | ENDOMETRIUM | 1083 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 3 | 1.11 | HEC265 | N | 4 | 0 | 0 | Y | ||||||||||||
| MSH6 | EDTPPLLRA | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1083 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 3 | 1.11 | KCL22 | N | 4 | 0 | 0 | Y | ||||||||||||
| MSH6 | EDTPPLLRA | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1083 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 3 | 1.11 | RCHACV | N | 4 | 0 | 0 | Y | ||||||||||||
| MSH6 | EDTPPLLRA | ENDOMETRIUM | 1083 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 3 | 1.11 | RL952 | N | 4 | 0 | 0 | Y | ||||||||||||
| MSH6 | EDTPPLLRA | LARGE_INTESTINE | 1083 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 3 | 1.11 | SNUC2A | N | 4 | 0 | 0 | Y | ||||||||||||
| MSH6 | EDTPPLLRA | LARGE_INTESTINE | 1083 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 3 | 1.11 | SW48 | N | 4 | 0 | 0 | Y | ||||||||||||
| MSH6 | EDTPPLLRA | PROSTATE | 1083 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 3 | 1.11 | VCAP | N | 4 | 0 | 0 | Y | ||||||||||||
| MSH6 | PEDTPPLLR | THYROID | 1082 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 2 | 1.11 | FTC238 | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH6 | PEDTPPLLR | LARGE_INTESTINE | 1082 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 2 | 1.11 | GP2D | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH6 | PEDTPPLLR | ENDOMETRIUM | 1082 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 2 | 1.11 | HEC151 | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH6 | PEDTPPLLR | ENDOMETRIUM | 1082 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 2 | 1.11 | HEC265 | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH6 | PEDTPPLLR | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1082 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 2 | 1.11 | KCL22 | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH6 | PEDTPPLLR | HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1082 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 2 | 1.11 | RCHACV | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH6 | PEDTPPLLR | ENDOMETRIUM | 1082 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 2 | 1.11 | RL952 | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH6 | PEDTPPLLR | LARGE_INTESTINE | 1082 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 2 | 1.11 | SNUC2A | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH6 | PEDTPPLLR | LARGE_INTESTINE | 1082 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 2 | 1.11 | SW48 | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH6 | PEDTPPLLR | PROSTATE | 1082 | p.T1085fs | c.3253_3254insC | Frame_Shift_Ins | 2 | 1.11 | VCAP | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH6 | ANAVVKKNL | LUNG | 1228 | p.V1232fs | c.3696_3697insAA | Frame_Shift_Ins | 3 | 0.11 | HCC2108 | N | 5 | 0 | 0 | N | ||||||||||||
| MSH6 | AVVKKNLLR | LUNG | 1230 | p.V1232fs | c.3696_3697insAA | Frame_Shift_Ins | 5 | 0.11 | HCC2108 | N | 6 | 0 | 0 | Y | ||||||||||||
| MSH6 | IANAVVKKN | LUNG | 1227 | p.V1232fs | c.3696_3697insAA | Frame_Shift_Ins | 2 | 0.11 | HCC2108 | N | 1 | 0 | 0 | N | ||||||||||||
| MSH6 | NAVVKKNLL | LUNG | 1229 | p.V1232fs | c.3696_3697insAA | Frame_Shift_Ins | 4 | 0.11 | HCC2108 | N | 16 | 0 | 0 | N | ||||||||||||
| MSH6 | VVKKNLLRL | LUNG | 1231 | p.V1232fs | c.3696_3697insAA | Frame_Shift_Ins | 5 | 0.11 | HCC2108 | Y | 8 | 13 | 28 | Y | ||||||||||||
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