Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MSH2 | APIWEVNQH | ENDOMETRIUM | 669 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | CSTSLLAPI | ENDOMETRIUM | 663 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 5 | 0 | 0 | N | ||||||||||||
| MSH2 | DVTLKKINR | ENDOMETRIUM | 654 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | Y | 5 | 9 | 0 | N | ||||||||||||
| MSH2 | ELSLGQSDT | SOFT_TISSUE | 786 | p.T788fs | c.2363_2364delCT | Frame_Shift_Del | 5 | 0.11 | SKUT1 | N | 1 | 0 | 0 | N | ||||||||||||
| MSH2 | EVNQHIFDK | ENDOMETRIUM | 673 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | Y | 5 | 11 | 0 | N | ||||||||||||
| MSH2 | FHELSLGQS | SOFT_TISSUE | 784 | p.T788fs | c.2363_2364delCT | Frame_Shift_Del | 5 | 0.11 | SKUT1 | N | 4 | 0 | 2 | N | ||||||||||||
| MSH2 | FIPNDVTLK | ENDOMETRIUM | 650 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 3 | 0.11 | HEC108 | N | 5 | 0 | 9 | N | ||||||||||||
| MSH2 | GSQSGCLAE | ENDOMETRIUM | 322 | p.S325fs | c.973_974delTC | Frame_Shift_Del | 5 | 0.11 | JHUEM1 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | HELSLGQSD | SOFT_TISSUE | 785 | p.T788fs | c.2363_2364delCT | Frame_Shift_Del | 5 | 0.11 | SKUT1 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | HFHELSLGQ | SOFT_TISSUE | 783 | p.T788fs | c.2363_2364delCT | Frame_Shift_Del | 4 | 0.11 | SKUT1 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | INRCSTSLL | ENDOMETRIUM | 660 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 7 | 0 | 8 | N | ||||||||||||
| MSH2 | IPNDVTLKK | ENDOMETRIUM | 651 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 3 | 0.11 | HEC108 | Y | 4 | 12 | 10 | N | ||||||||||||
| MSH2 | IWEVNQHIF | ENDOMETRIUM | 671 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 4 | 0 | 0 | N | ||||||||||||
| MSH2 | KINRCSTSL | ENDOMETRIUM | 659 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | Y | 10 | 10 | 0 | N | ||||||||||||
| MSH2 | KKINRCSTS | ENDOMETRIUM | 658 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 2 | 0 | 0 | N | ||||||||||||
| MSH2 | LAPIWEVNQ | ENDOMETRIUM | 668 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 6 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | LKKINRCST | ENDOMETRIUM | 657 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 1 | 0 | 1 | N | ||||||||||||
| MSH2 | LLAPIWEVN | ENDOMETRIUM | 667 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | LSLGQSDTN | SOFT_TISSUE | 787 | p.T788fs | c.2363_2364delCT | Frame_Shift_Del | 5 | 0.11 | SKUT1 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | NDVTLKKIN | ENDOMETRIUM | 653 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 2 | 0 | 0 | N | ||||||||||||
| MSH2 | NQHIFDKLG | ENDOMETRIUM | 675 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | NRCSTSLLA | ENDOMETRIUM | 661 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 2 | 0 | 0 | N | ||||||||||||
| MSH2 | PIWEVNQHI | ENDOMETRIUM | 670 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 2 | 0 | 0 | N | ||||||||||||
| MSH2 | PNDVTLKKI | ENDOMETRIUM | 652 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 4 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | RCSTSLLAP | ENDOMETRIUM | 662 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | SLGQSDTNC | SOFT_TISSUE | 788 | p.T788fs | c.2363_2364delCT | Frame_Shift_Del | 6 | 0.11 | SKUT1 | N | 2 | 0 | 0 | N | ||||||||||||
| MSH2 | SLLAPIWEV | ENDOMETRIUM | 666 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | Y | 8 | 9 | 0 | N | ||||||||||||
| MSH2 | STSLLAPIW | ENDOMETRIUM | 664 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 1 | 0 | 0 | N | ||||||||||||
| MSH2 | TGSQSGCLA | ENDOMETRIUM | 321 | p.S325fs | c.973_974delTC | Frame_Shift_Del | 4 | 0.11 | JHUEM1 | N | 1 | 0 | 0 | N | ||||||||||||
| MSH2 | THFHELSLG | SOFT_TISSUE | 782 | p.T788fs | c.2363_2364delCT | Frame_Shift_Del | 3 | 0.11 | SKUT1 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | TLKKINRCS | ENDOMETRIUM | 656 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 1 | 0 | 0 | N | ||||||||||||
| MSH2 | TSLLAPIWE | ENDOMETRIUM | 665 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | TTGSQSGCL | ENDOMETRIUM | 320 | p.S325fs | c.973_974delTC | Frame_Shift_Del | 3 | 0.11 | JHUEM1 | N | 4 | 0 | 0 | N | ||||||||||||
| MSH2 | VNQHIFDKL | ENDOMETRIUM | 674 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 4 | 0.11 | HEC108 | N | 11 | 0 | 0 | N | ||||||||||||
| MSH2 | VTLKKINRC | ENDOMETRIUM | 655 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 1 | 0 | 13 | N | ||||||||||||
| MSH2 | WEVNQHIFD | ENDOMETRIUM | 672 | p.Y656fs | c.1966_1966delT | Frame_Shift_Del | 5 | 0.11 | HEC108 | N | 3 | 0 | 1 | N | ||||||||||||
| MSH2 | LSELSKRNN | ENDOMETRIUM | 478 | p.L481fs | c.1441_1442insTAAG | Frame_Shift_Ins | 4 | 0.11 | HEC59 | N | 1 | 0 | 0 | N | ||||||||||||
| MSH2 | NLSELSKRN | ENDOMETRIUM | 477 | p.L481fs | c.1441_1442insTAAG | Frame_Shift_Ins | 4 | 0.11 | HEC59 | N | 0 | 0 | 0 | N | ||||||||||||
| MSH2 | PNLSELSKR | ENDOMETRIUM | 476 | p.L481fs | c.1441_1442insTAAG | Frame_Shift_Ins | 3 | 0.11 | HEC59 | N | 0 | 0 | 0 | Y | ||||||||||||
| MSH2 | SELSKRNNE | ENDOMETRIUM | 479 | p.L481fs | c.1441_1442insTAAG | Frame_Shift_Ins | 4 | 0.11 | HEC59 | N | 1 | 0 | 0 | N | ||||||||||||
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