Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
| Result | Search: | |||||||||||||||||||||||||
| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MET | ANLGHQRVA | STOMACH | 453 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 5 | 0.11 | MKN74 | N | 1 | 0 | 0 | N | ||||||||||||
| MET | ASCRLWFLD | STOMACH | 461 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 0 | 0 | 0 | N | ||||||||||||
| MET | CRLWFLDQD | STOMACH | 463 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 1 | 0 | 0 | N | ||||||||||||
| MET | DVYLSSEIL | LARGE_INTESTINE | 236 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 10 | 0 | 0 | N | ||||||||||||
| MET | EILTPLSMS | LARGE_INTESTINE | 242 | p.V237fs | c.710_710delT | Frame_Shift_Del | 6 | 0.11 | HCT116 | N | 1 | 0 | 0 | N | ||||||||||||
| MET | FLDQDHQPL | STOMACH | 467 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 14 | 0 | 0 | N | ||||||||||||
| MET | GHQRVASCR | STOMACH | 456 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 1 | 0 | 0 | N | ||||||||||||
| MET | HQRVASCRL | STOMACH | 457 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 8 | 0 | 0 | N | ||||||||||||
| MET | IANLGHQRV | STOMACH | 452 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 4 | 0.11 | MKN74 | N | 5 | 0 | 0 | N | ||||||||||||
| MET | IDVYLSSEI | LARGE_INTESTINE | 235 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 7 | 0 | 2 | N | ||||||||||||
| MET | ILTPLSMSM | LARGE_INTESTINE | 243 | p.V237fs | c.710_710delT | Frame_Shift_Del | 6 | 0.11 | HCT116 | N | 7 | 0 | 0 | N | ||||||||||||
| MET | LDQDHQPLM | STOMACH | 468 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 5 | 0 | 0 | N | ||||||||||||
| MET | LGHQRVASC | STOMACH | 455 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 5 | 0.11 | MKN74 | N | 1 | 0 | 5 | N | ||||||||||||
| MET | LKATILFTS | LARGE_INTESTINE | 253 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 1 | 0 | 0 | N | ||||||||||||
| MET | LSMSMPLKA | LARGE_INTESTINE | 247 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 4 | 0 | 11 | N | ||||||||||||
| MET | LSSEILTPL | LARGE_INTESTINE | 239 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 16 | 0 | 0 | N | ||||||||||||
| MET | LTPLSMSMP | LARGE_INTESTINE | 244 | p.V237fs | c.710_710delT | Frame_Shift_Del | 6 | 0.11 | HCT116 | N | 0 | 0 | 0 | N | ||||||||||||
| MET | LWFLDQDHQ | STOMACH | 465 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 0 | 0 | 0 | N | ||||||||||||
| MET | MPLKATILF | LARGE_INTESTINE | 251 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 13 | 0 | 4 | N | ||||||||||||
| MET | MSMPLKATI | LARGE_INTESTINE | 249 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 9 | 0 | 0 | N | ||||||||||||
| MET | NLGHQRVAS | STOMACH | 454 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 5 | 0.11 | MKN74 | N | 0 | 0 | 0 | N | ||||||||||||
| MET | PLKATILFT | LARGE_INTESTINE | 252 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 0 | 0 | 0 | N | ||||||||||||
| MET | PLSMSMPLK | LARGE_INTESTINE | 246 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 1 | 0 | 0 | N | ||||||||||||
| MET | QRVASCRLW | STOMACH | 458 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 2 | 0 | 0 | N | ||||||||||||
| MET | RLWFLDQDH | STOMACH | 464 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 2 | 0 | 0 | N | ||||||||||||
| MET | RVASCRLWF | STOMACH | 459 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | Y | 5 | 10 | 0 | N | ||||||||||||
| MET | SCRLWFLDQ | STOMACH | 462 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 0 | 0 | 0 | N | ||||||||||||
| MET | SEILTPLSM | LARGE_INTESTINE | 241 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 7 | 0 | 0 | N | ||||||||||||
| MET | SMPLKATIL | LARGE_INTESTINE | 250 | p.V237fs | c.710_710delT | Frame_Shift_Del | 6 | 0.11 | HCT116 | N | 13 | 0 | 0 | N | ||||||||||||
| MET | SMSMPLKAT | LARGE_INTESTINE | 248 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 2 | 0 | 0 | N | ||||||||||||
| MET | SSEILTPLS | LARGE_INTESTINE | 240 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 1 | 0 | 0 | N | ||||||||||||
| MET | SYIDVYLSS | LARGE_INTESTINE | 233 | p.V237fs | c.710_710delT | Frame_Shift_Del | 4 | 0.11 | HCT116 | N | 3 | 0 | 0 | N | ||||||||||||
| MET | TPLSMSMPL | LARGE_INTESTINE | 245 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 21 | 0 | 0 | N | ||||||||||||
| MET | VASCRLWFL | STOMACH | 460 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | Y | 18 | 10 | 0 | N | ||||||||||||
| MET | VYLSSEILT | LARGE_INTESTINE | 237 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 3 | 0 | 0 | N | ||||||||||||
| MET | WFLDQDHQP | STOMACH | 466 | p.G456fs | c.1366_1366delG | Frame_Shift_Del | 6 | 0.11 | MKN74 | N | 2 | 0 | 0 | N | ||||||||||||
| MET | YIDVYLSSE | LARGE_INTESTINE | 234 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 2 | 0 | 0 | N | ||||||||||||
| MET | YLSSEILTP | LARGE_INTESTINE | 238 | p.V237fs | c.710_710delT | Frame_Shift_Del | 5 | 0.11 | HCT116 | N | 3 | 0 | 5 | N | ||||||||||||
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