Cancertope: In silico Platform for designing genome-based Personalized immunotherapy or Vaccine against Cancer

Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click HERE

Protein	Neoepitopes	Tissue	Position	Prot Mutation	cDNA Mutation	Mutation Type	Num Mismatch	Promiscuity (%)	Cell Line	CTL	MHC I	NHLApred	MHC II	Bcell
Result		Search:
CTBP2	AERHGIQCK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	144	p.V120fs	c.358_358delG	Frame_Shift_Del	6	0.11	AMO1	Y	1	11	0	N
CTBP2	CRTPVTCTG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	158	p.V120fs	c.358_358delG	Frame_Shift_Del	6	0.11	AMO1	N	1	0	0	N
CTBP2	ERHGIQCKA	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	145	p.V120fs	c.358_358delG	Frame_Shift_Del	6	0.11	AMO1	Y	1	9	0	N
CTBP2	GTQESAGRS	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	128	p.V120fs	c.358_358delG	Frame_Shift_Del	6	0.11	AMO1	N	1	0	0	N
CTBP2	HGIQCKAGH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	147	p.V120fs	c.358_358delG	Frame_Shift_Del	6	0.11	AMO1	N	0	0	0	N
CTBP2	IGTQESAGR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	127	p.V120fs	c.358_358delG	Frame_Shift_Del	6	0.11	AMO1	N	1	0	0	N
CTBP2	RHGIQCKAG	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	146	p.V120fs	c.358_358delG	Frame_Shift_Del	6	0.11	AMO1	N	0	0	0	N
CTBP2	RTPVTCTGI	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	159	p.V120fs	c.358_358delG	Frame_Shift_Del	6	0.11	AMO1	N	4	0	0	N
CTBP2	TCTGILEVK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	163	p.V120fs	c.358_358delG	Frame_Shift_Del	6	0.11	AMO1	N	2	0	0	N
CTBP2	VTCTGILEV	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	162	p.V120fs	c.358_358delG	Frame_Shift_Del	6	0.11	AMO1	Y	7	9	2	N
CTBP2	DTEQGCISR	SKIN	178	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	IPC298	N	5	0	0	N
CTBP2	DTEQGCISR	BREAST	178	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	MDAMB468	N	5	0	0	N
CTBP2	DTEQGCISR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	178	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	NUDUL1	N	5	0	0	N
CTBP2	DTEQGCISR	OVARY	178	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	OVCAR4	N	5	0	0	N
CTBP2	GLQRHQRKT	SKIN	209	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	IPC298	N	1	0	0	N
CTBP2	GLQRHQRKT	BREAST	209	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	MDAMB468	N	1	0	0	N
CTBP2	GLQRHQRKT	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	209	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	NUDUL1	N	1	0	0	N
CTBP2	GLQRHQRKT	OVARY	209	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	OVCAR4	N	1	0	0	N
CTBP2	HQVWGGGAC	SKIN	195	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	IPC298	N	2	0	0	N
CTBP2	HQVWGGGAC	BREAST	195	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	MDAMB468	N	2	0	0	N
CTBP2	HQVWGGGAC	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	195	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	NUDUL1	N	2	0	0	N
CTBP2	HQVWGGGAC	OVARY	195	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	OVCAR4	N	2	0	0	N
CTBP2	LQRHQRKTH	SKIN	210	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	IPC298	N	0	0	21	N
CTBP2	LQRHQRKTH	BREAST	210	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	MDAMB468	N	0	0	21	N
CTBP2	LQRHQRKTH	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	210	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	NUDUL1	N	0	0	21	N
CTBP2	LQRHQRKTH	OVARY	210	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	OVCAR4	N	0	0	21	N
CTBP2	PGLQRHQRK	SKIN	208	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	IPC298	N	0	0	0	N
CTBP2	PGLQRHQRK	BREAST	208	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	MDAMB468	N	0	0	0	N
CTBP2	PGLQRHQRK	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	208	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	NUDUL1	N	0	0	0	N
CTBP2	PGLQRHQRK	OVARY	208	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	OVCAR4	N	0	0	0	N
CTBP2	PQPGLQRHQ	SKIN	206	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	IPC298	N	0	0	0	N
CTBP2	PQPGLQRHQ	BREAST	206	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	MDAMB468	N	0	0	0	N
CTBP2	PQPGLQRHQ	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	206	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	NUDUL1	N	0	0	0	N
CTBP2	PQPGLQRHQ	OVARY	206	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	OVCAR4	N	0	0	0	N
CTBP2	QPGLQRHQR	SKIN	207	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	IPC298	N	3	0	0	N
CTBP2	QPGLQRHQR	BREAST	207	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	MDAMB468	N	3	0	0	N
CTBP2	QPGLQRHQR	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	207	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	NUDUL1	N	3	0	0	N
CTBP2	QPGLQRHQR	OVARY	207	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	OVCAR4	N	3	0	0	N
CTBP2	QVWGGGACL	SKIN	196	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	IPC298	N	12	0	0	N
CTBP2	QVWGGGACL	BREAST	196	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	MDAMB468	N	12	0	0	N
CTBP2	QVWGGGACL	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	196	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	NUDUL1	N	12	0	0	N
CTBP2	QVWGGGACL	OVARY	196	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	OVCAR4	N	12	0	0	N
CTBP2	VWGGGACLP	SKIN	197	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	IPC298	N	0	0	0	N
CTBP2	VWGGGACLP	BREAST	197	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	MDAMB468	N	0	0	0	N
CTBP2	VWGGGACLP	HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	197	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	NUDUL1	N	0	0	0	N
CTBP2	VWGGGACLP	OVARY	197	p.Q175fs	c.524_525delAG	Frame_Shift_Del	6	0.44	OVCAR4	N	0	0	0	N
CTBP2	VQQLQPPKR	ENDOMETRIUM	369	p.G362fs	c.1085_1086insG	Frame_Shift_Ins	6	0.11	HEC108	N	5	0	5	N