Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHD1 | VREVQRGEK | PROSTATE | 1325 | p.K1320fs | c.3960_3960delA | Frame_Shift_Del | 6 | 0.11 | 22RV1 | N | 3 | 0 | 3 | N | ||||||||||||
| CHD1 | MIMIKEVLV | OVARY | 225 | p.K210fs | c.629_629delA | Frame_Shift_Del | 6 | 0.22 | IGROV1 | N | 5 | 0 | 2 | N | ||||||||||||
| CHD1 | MIMIKEVLV | LARGE_INTESTINE | 225 | p.K210fs | c.629_629delA | Frame_Shift_Del | 6 | 0.22 | LS180 | N | 5 | 0 | 2 | N | ||||||||||||
| CHD1 | MMKKIMIMI | OVARY | 220 | p.K210fs | c.629_629delA | Frame_Shift_Del | 6 | 0.22 | IGROV1 | N | 10 | 0 | 0 | N | ||||||||||||
| CHD1 | MMKKIMIMI | LARGE_INTESTINE | 220 | p.K210fs | c.629_629delA | Frame_Shift_Del | 6 | 0.22 | LS180 | N | 10 | 0 | 0 | N | ||||||||||||
| CHD1 | MMMKKIMIM | OVARY | 219 | p.K210fs | c.629_629delA | Frame_Shift_Del | 6 | 0.22 | IGROV1 | N | 9 | 0 | 36 | N | ||||||||||||
| CHD1 | MMMKKIMIM | LARGE_INTESTINE | 219 | p.K210fs | c.629_629delA | Frame_Shift_Del | 6 | 0.22 | LS180 | N | 9 | 0 | 36 | N | ||||||||||||
| CHD1 | RMMMKKIMI | OVARY | 218 | p.K210fs | c.629_629delA | Frame_Shift_Del | 6 | 0.22 | IGROV1 | N | 13 | 0 | 0 | N | ||||||||||||
| CHD1 | RMMMKKIMI | LARGE_INTESTINE | 218 | p.K210fs | c.629_629delA | Frame_Shift_Del | 6 | 0.22 | LS180 | N | 13 | 0 | 0 | N | ||||||||||||
| CHD1 | RRMMMKKIM | OVARY | 217 | p.K210fs | c.629_629delA | Frame_Shift_Del | 6 | 0.22 | IGROV1 | N | 4 | 0 | 0 | N | ||||||||||||
| CHD1 | RRMMMKKIM | LARGE_INTESTINE | 217 | p.K210fs | c.629_629delA | Frame_Shift_Del | 6 | 0.22 | LS180 | N | 4 | 0 | 0 | N | ||||||||||||
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