Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CBL | CLGSEARSV | LUNG | 634 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 5 | 0.11 | VMRCLCP | Y | 3 | 9 | 0 | N | ||||||||||||
| CBL | DQMCLGSEA | LUNG | 631 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 5 | 0.11 | VMRCLCP | N | 1 | 0 | 0 | N | ||||||||||||
| CBL | EARSVWIPP | LUNG | 638 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 6 | 0.11 | VMRCLCP | N | 0 | 0 | 0 | N | ||||||||||||
| CBL | GSEARSVWI | LUNG | 636 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 6 | 0.11 | VMRCLCP | N | 4 | 0 | 0 | N | ||||||||||||
| CBL | GSGARVRVA | STOMACH | 16 | p.G18fs | c.52_52delG | Frame_Shift_Del | 5 | 0.11 | 2313287 | Y | 1 | 11 | 0 | N | ||||||||||||
| CBL | GSGSGARVR | STOMACH | 14 | p.G18fs | c.52_52delG | Frame_Shift_Del | 4 | 0.11 | 2313287 | Y | 3 | 9 | 0 | N | ||||||||||||
| CBL | LGSEARSVW | LUNG | 635 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 6 | 0.11 | VMRCLCP | N | 3 | 0 | 0 | N | ||||||||||||
| CBL | LPSQRSPDQ | LUNG | 624 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 4 | 0.11 | VMRCLCP | N | 1 | 0 | 0 | N | ||||||||||||
| CBL | MCLGSEARS | LUNG | 633 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 5 | 0.11 | VMRCLCP | N | 0 | 0 | 0 | N | ||||||||||||
| CBL | PDQMCLGSE | LUNG | 630 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 4 | 0.11 | VMRCLCP | N | 0 | 0 | 0 | N | ||||||||||||
| CBL | PSQRSPDQM | LUNG | 625 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 5 | 0.11 | VMRCLCP | N | 0 | 0 | 0 | N | ||||||||||||
| CBL | QMCLGSEAR | LUNG | 632 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 6 | 0.11 | VMRCLCP | N | 6 | 0 | 0 | N | ||||||||||||
| CBL | QRSPDQMCL | LUNG | 627 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 5 | 0.11 | VMRCLCP | N | 6 | 0 | 0 | N | ||||||||||||
| CBL | RSPDQMCLG | LUNG | 628 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 5 | 0.11 | VMRCLCP | N | 0 | 0 | 0 | N | ||||||||||||
| CBL | SEARSVWIP | LUNG | 637 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 6 | 0.11 | VMRCLCP | N | 1 | 0 | 0 | N | ||||||||||||
| CBL | SGSGARVRV | STOMACH | 15 | p.G18fs | c.52_52delG | Frame_Shift_Del | 5 | 0.11 | 2313287 | Y | 4 | 10 | 0 | N | ||||||||||||
| CBL | SPDQMCLGS | LUNG | 629 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 4 | 0.11 | VMRCLCP | N | 2 | 0 | 0 | N | ||||||||||||
| CBL | SQRSPDQMC | LUNG | 626 | p.M628fs | c.1883_1883delT | Frame_Shift_Del | 5 | 0.11 | VMRCLCP | N | 2 | 0 | 0 | N | ||||||||||||
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