Cancertope
In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer
Personalized immunotherapy or Vaccine against Cancer
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The result page of search shows exclusive peptide/epitopes generated due to mutation [Neoepitope], the tissue of origin [Tissue], position of peptide in protein [Position], number of mismatches counted by aligning mutated and normal protein sequence [Num Mismatch, percentage of cell lines with this peptide over total number of cell lines [Promiscuity %]. The immune information include CTL epitopes (Yes/No), MHC I binders, MHC II binders (both given as number of alleles) and B cell epitopes (Yes/No). For more information, please click |
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| Protein | Neoepitopes | Tissue | Position | Prot Mutation | cDNA Mutation | Mutation Type | Num Mismatch | Promiscuity (%) | Cell Line | CTL | MHC I | NHLApred | MHC II | Bcell | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKAP12 | QYAPKFKFR | ENDOMETRIUM | 1405 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 6 | 0.11 | EN | Y | 2 | 11 | 0 | N | ||||||||||||
| AKAP12 | RQYAPKFKF | ENDOMETRIUM | 1404 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 6 | 0.11 | EN | N | 12 | 0 | 0 | N | ||||||||||||
| AKAP12 | YAPKFKFRA | ENDOMETRIUM | 1406 | p.E1403fs | c.4209_4209delG | Frame_Shift_Del | 6 | 0.11 | EN | N | 8 | 0 | 12 | N | ||||||||||||
| AKAP12 | FQFCVPGRN | LARGE_INTESTINE | 1225 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 6 | 0.11 | RKO | N | 4 | 0 | 5 | N | ||||||||||||
| AKAP12 | STFQFCVPG | LARGE_INTESTINE | 1223 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 6 | 0.11 | RKO | N | 0 | 0 | 0 | N | ||||||||||||
| AKAP12 | TFQFCVPGR | LARGE_INTESTINE | 1224 | p.S1206fs | c.3618_3619insG | Frame_Shift_Ins | 6 | 0.11 | RKO | N | 2 | 0 | 0 | N | ||||||||||||
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