Primary information |
---|
CancerPPD ID | 5006 |
PMID | 24587350 |
YEAR | 2014 |
SEQUENCE | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES |
LENGTH | 37 |
NAME | LL 37 |
C-ter Modification | Free |
N-ter Modification | Free |
Linear/Cyclic | Linear |
L/D/Mix | L |
Non-Natural | None |
NATURE | Antimicrobial |
ACTIVITY | LC50= 24 at 100 µM |
SOURCE | Also known human cathelicidin |
Cancer Type | Ovarian Cancer |
ASSAY | MTT/MTS assay |
Patent ID | None |
Tissue | Ovary |
CELL LINE | OVRCAR-3 |
TEST TIME | 72-h |
Secondary information |
---|
STRUCTURE | |
DSSP states | CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCSSCCC |
SMILES | [NH3][C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CO)CCC(=O)O)[C@H](O)C)CCCNC(=[NH2])N)CCC1)C(C)C)CC(C)C)CC(=O)N)CCCNC(=[NH2])N)CC(C)C)Cc1ccccc1)CC(=O)O)CCCC[NH3])[C@H](CC)C)CCCNC(=[NH2])N)CCC(=O)N)C(C)C)[C@H](CC)C)CCCNC(=[NH2])N)CCCC[NH3])Cc1ccccc1)CCC(=O)O)CCCC[NH3])[C@H](CC)C)CCCC[NH3])CCC(=O)O)CCCC[NH3])CO)CCCC[NH3])CCCNC(=[NH2])N)Cc1ccccc1)Cc1ccccc1)CC(=O)O)CC(C)C)CC(C)C |
External Links |
---|
PDB exact | PDB partial | SP exact | SP partial | TrEMBL exact | TrEMBL partial | IEDB exact | IEDB partial |
2k6oA | NA | NA | >sp_P49913_CAMP_HUMANCathelicidinantimicrobialpe | NA | >tr_J3KNB4_J3KNB4_HUMANCathelicidinantimicrobialpeptideOS=HomosapiensGN=CAMPPE=4SV=1 | NA | NA |
|