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2919 details
Primary information
CancerPPD ID2919
PMID21849092
YEAR2011
SEQUENCETHRPPMWSPVWPGGGKLlLKlLkkLLKlLKKK
LENGTH32
NAMETransferrin receptor (TfR)-lytic hybrid peptide
C-ter ModificationFree
N-ter ModificationFree
Linear/CyclicLinear
L/D/MixMix
Non-NaturalNone
NATUREAnticancer
ACTIVITYIC50= 6.3 µM
SOURCETransferrin receptor (TfR)
Cancer TypeBrain Tumor
ASSAYWST-1 assay
Patent IDNone
TissueBrain
CELL LINESF-295
TEST TIME72-h
Secondary information
STRUCTURE
Predicted Structure
DSSP statesCCSSSSSCSSCCCTHHHHHHHHHHHHHHHHHC
SMILESN[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1c[nH]c(C)c1CC)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
External Links
PDB exactPDB partialSP exactSP partialTrEMBL exactTrEMBL partialIEDB exactIEDB partial
NANANANA>tr_Q95VE8_Q95VE8_MUSDOCecropinOS=MuscadomesticaGN=Cep1PE=3SV=1NANANA