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KWKSFLKTFKSLKKTKLHTLLKLISS details |
Primary information | |
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ID | antitb_1310, |
Name | 20858205 |
N-Terminal modification | D-(V13K,A12L,A20L,A23L,V16K) D5 |
C-Terminal Modification | KWKSFLKTFKSLKKTKLHTLLKLISS |
Chemical Modification | Acetylation |
Linear/Cyclic | Amidation |
Length | None |
Chirality | Linear |
Nature | 26 |
Source | L |
Origin | Cationic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium tuberculosis |
In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv |
Cell Line | MIC = 35.2 μg/mL |
Inhibition Concentration | In vitro |
Sequence | 2011 |
Cytotoxicity | Human erythrocyte |
In vivo Model | NA |
Lethal Dose | HC50 = 47 μg/mL |
Immune Responce | NA |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | NA |
Other activities | NA |
PMID | NA |
Year of Publication | NA |
Tertiary Structure (Technique) | Not Predicted), |
Primary information | |
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ID | antitb_1315, |
Name | 20858205 |
N-Terminal modification | D-(V13K,A12L,A20L,A23L,V16K) D5 |
C-Terminal Modification | KWKSFLKTFKSLKKTKLHTLLKLISS |
Chemical Modification | Acetylation |
Linear/Cyclic | Amidation |
Length | None |
Chirality | Linear |
Nature | 26 |
Source | L |
Origin | Cationic |
Species | Synthetic |
Inhibition Concentration | Mycobacterium tuberculosis |
In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv multidrug resistant strain vertulo |
Cell Line | MIC = 49 μg/mL |
Inhibition Concentration | In vitro |
Sequence | 2011 |
Cytotoxicity | Human erythrocyte |
In vivo Model | NA |
Lethal Dose | HC50 = 1.0 μg/mL |
Immune Responce | NA |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | NA |
Other activities | NA |
PMID | NA |
Year of Publication | NA |
Tertiary Structure (Technique) | Not Predicted), |
Primary information | |
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ID | antitb_1530, |
Name | 25613372 |
N-Terminal modification | D5 |
C-Terminal Modification | KWKSFLKTFKSLKKTKLHTLLKLISS |
Chemical Modification | Acetylation |
Linear/Cyclic | Amidation |
Length | None |
Chirality | Linear |
Nature | 27 |
Source | L |
Origin | Cationic |
Species | Protein derived |
Strain | Derived from Human cationic antimicrobial protein 18 (hCAP18) |
Inhibition Concentration | Mycobacterium tuberculosis |
In Vitro/ In vivo | Mycobacterium tuberculosis H37Rv |
Cell Line | MIC = 35.2 μg/ml |
Inhibition Concentration | in vitro |
Sequence | 2015 |
Cytotoxicity | Human macrophage THP1 |
In vivo Model | NA |
Lethal Dose | No cytotoxicity |
Immune Responce | NA |
Mechanism of Action | NA |
Target | Induce expression of IL-8and MCP-1 |
Combination Therapy | In vitro binding of bacterilamembrane and induce pore formation while in vivo activate TLR and monocyte to kill bacteria |
Other activities | Bacterial cell membrane |
PMID | NA |
Year of Publication | NA |
Tertiary Structure (Technique) | Not Predicted), |
Primary information | |
---|---|
ID | antitb_1531, |
Name | 25613372 |
N-Terminal modification | D5 |
C-Terminal Modification | KWKSFLKTFKSLKKTKLHTLLKLISS |
Chemical Modification | Acetylation |
Linear/Cyclic | Amidation |
Length | None |
Chirality | Linear |
Nature | 27 |
Source | L |
Origin | Cationic |
Species | Protein derived |
Strain | Derived from Human cationic antimicrobial protein 18 (hCAP18) |
Inhibition Concentration | Mycobacterium tuberculosis |
In Vitro/ In vivo | Mycobacterium tuberculosis MDR-TB |
Cell Line | MIC = 49 μg/ml |
Inhibition Concentration | in vitro |
Sequence | 2015 |
Cytotoxicity | Human macrophage THP1 |
In vivo Model | NA |
Lethal Dose | No cytotoxicity |
Immune Responce | NA |
Mechanism of Action | NA |
Target | Induce expression of IL-8and MCP-1 |
Combination Therapy | In vitro binding of bacterilamembrane and induce pore formation while in vivo activate TLR and monocyte to kill bacteria |
Other activities | Bacterial cell membrane |
PMID | NA |
Year of Publication | NA |
Tertiary Structure (Technique) | Not Predicted), |