| Primary information |
|---|
| ID | antitb_1333 |
| Peptide Name | Innate defence regulator peptide 1018 |
| Sequence | VRLIVAVRIWRR |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Length | 12 |
| Chirality | L |
| Nature | Cationic |
| Source | Synthetic |
| Origin | NA |
| Species | Mycobacterium tuberculosis |
| Strain | Mycobacterium tuberculosis H37Rv |
| Inhibition Concentartion | MIC = 16.4± 5.4 mg/mL |
| In vitro/In vivo | Both |
| Cell Line | Human U937 promonocytic cell line |
| Inhibition Concentartion | NA |
| Cytotoxicity | None |
| In vivo Model | BALB/C |
| Lethal Dose | 32 mg in 100 mL of saline solution (1 mg/kg) |
| Immune Response | Increase expression of MCP-1,Gro-α and TNF-α |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other Activities | Antimicrobial against plasmodium aeruginosa/ S. aureus |
| Pubmed ID | 23555622 |
| Year of Publication | 2012 |
| 3-D Structure |  View in Jmol or Download Structure |