| Primary information |
|---|
| ID | antitb_1199 |
| Peptide Name | Pinanediol PD-protected Boropentapeptide |
| Sequence | AVKAA-BO2(PD) |
| N-terminal Modification | Free |
| C-terminal Modification | Conjugated with Boronic acid and pinanediol PD |
| Chemical Modification | Conjugated with Boronic acid and pinanediol PD |
| Linear/ Cyclic | Linear |
| Length | 5 |
| Chirality | L |
| Nature | NA |
| Source | Synthetic |
| Origin | NA |
| Species | Mycobacterium smegmatis |
| Strain | Mycobacterium smegmatis |
| Inhibition Concentartion | IC50 = 93.2±33.7 μM for MycP2 |
| In vitro/In vivo | In vitro |
| Cell Line | None |
| Inhibition Concentartion | NA |
| Cytotoxicity | NA |
| In vivo Model | None |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | Inhibit enzyme (MycP1) reponsible for cleavage of virulence factor (ESX secretion-associated protein B (EspB)) |
| Target | Mycosin protease-1 (MycP1) |
| Combination Therapy | None |
| Other Activities | None |
| Pubmed ID | 24915878 |
| Year of Publication | 2014 |
| 3-D Structure |  View in Jmol or Download Structure |