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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 67
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1737FKAB-1FKL-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-Oic-KRFreeAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear21LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 30 μMBothRBCNA63 % hemolysis at 100 and 25 μM Mice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1738FKAB-1GGF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothRBCNA14 % hemolysis at 100 and 25 μMMice No observed toxicity at 5 and 25 mg/kg but minor NANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1739FKAB-1HGF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKAcetylationAddition of CONH-CH2-CH2-NH2Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothRBCNANAMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1740FKAB-1LGF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKAcetylationAddition of CONH-CH2-CH2-CH2-NH2Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothRBCNANAMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1741FKAB-1GaG-GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKFreeAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear20LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothRBCNA33.4 % hemolysis at 100 μM and 14.3 % at 25 μMMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1742FKAB-1GbG-KL-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKFreeAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear20LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 3 μMBothRBCNA43.6 % hemolysis at 100 μM and 24.9 % at 25 μMMice No observed toxicity at 1, 5 and 25 mg/kgNANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1743FKAB-1GcF-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear15LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 30 μMBothRBCNA86.8 % hemolysis at 100 μM and 50 % at 25 μMMice Minor weight loss, no observed toxicity at 1, 5 anNANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1744FKAB-1GdGaba-F-Tic-Oic-Gaba-K-Tic-Oic-Gaba-F-Tic-Oic-Gaba-K-Tic-KKKKAcetylationAmidationGaba = Gama aminobutyric acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothRBCNA10.8 % hemolysis at 100 μM and 1.0 % at 25 μMMice Minor weight loss, no observed toxicity at 1, 5 anNANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1745FKAB-1GeG-Tic-Oic-K-Tic-Oic-G-Tic-Oic-K-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear15LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 3 μMBothRBCNA26.7 % hemolysis at 100 μM and 9.2 % at 25 μMMice No observed toxicity at 1, 5 and 25 mg/kgNANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1746FKAB-1GfGF-Oic-GK-Oic-GF-Oic-GKKKKKAcetylationAmidationOic = Octahydroindolecarboxylic acidLinear15LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 100 μMBothRBCNA5.9 % hemolysis at 100 μM and 3.2 % at 25 μMMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1747FKAB-1GgGF-Tic-GK-Tic-GF-Tic-GK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acidLinear16LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 30 μMBothRBCNA6 % hemolysis at 100 μM and 4.9 % at 25 μMMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1748FKAB-1Gg1GF-Tic-G-GK-Tic-G-GF-Tic-G-GK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 30 μMBothRBCNA5.70 % hemolysis at 100 μM and 3.80 % at 25 μMMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1749FKAB-1Gf1GF-G-Oic-GK-G-Oic-GF-G-Oic-GK-G-KKKKAcetylationAmidationOic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 100 μMBothRBCNA3.30 % hemolysis at 100 μM and 3.3 % at 25 μMMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1750FKAB-1GhGF-F-Oic-GK-F-Oic-GF-F-Oic-GK-F-KKKKAcetylationAmidationOic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothRBCNA27.30 % hemolysis at 100 μM and 8.9 % at 25 μMMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1751FKAB-1Gd1βAla-F-Tic-Oic-βAla-K-Tic-Oic-βAla-F-Tic-Oic-βAla-K-Tic-KKKKAcetylationAmidationβAla = Beta alanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 1 μMBothRBCNA24.4 % hemolysis at 100 μM and 7.4 % at 25 μMMice No observed toxicity at 5 and 25 mg/kg but minor wNANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1752FKAB-1Gd2Ahx-F-Tic-Oic-Ahx-K-Tic-Oic-Ahx-F-Tic-Oic-Ahx-K-Tic-KKKKAcetylationAmidationAhx = 6-amino hexanoic acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 3 μMBothRBCNA44.7 % hemolysis at 100 μM and 26.6 % at 25 μMMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1753FKAB-1Gc1F-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-KKKKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear17LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 3 μMBothRBCNA41.3 % hemolysis at 100 μM and 33.5 % at 25 μMMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1754FKAB-1GiGF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear20LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 3 μMBothRBCNA24.9 % hemolysis at 100 μM and 18.9 % at 25 μMMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1755FKAB-1Gd3Gaba-F-Tic-Oic-Gaba-K-Tic-Oic-Gaba-F-Tic-Oic-Gaba-K-Tic-KKKKKAcetylationAmidationGaba = Gama aminobutyric acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear20LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 3 μMBothRBCNA29.7 % hemolysis at 100 μM and 10.5 % at 25 μMMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1756FKAB-1GjGF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-Orn-Orn-Orn-OrnAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = OrnithineLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1757FKAB-1GoG-Fpa-Tic-Oic-GK-Tic-Oic-G-Fpa-Tic-Oic-GK-Tic-KKKKAcetylationAmidationFpa = 4-Fluorophenyl alanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 3 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1758FKAB-1GpGF-Tic-Oic-G-Orn-Tic-Oic-GF-Tic-Oic-G-Orn-Tic-Orn-Orn-Orn-OrnAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = OrnithineLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1759FKAB-1GlBiotin-GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKBiotinylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1760FKAB-1GsGF-Tic-Oic-G-Dpr-Tic-Oic-GF-Tic-Oic-G-Dpr-Tic-Dpr-Dpr-Dpr-DprAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Dpr = 2,3-diaminopropanoic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 100 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1761FKAB-1GwβAla-Fpa-Tic-Oic-βAla-Dpr-Tic-Oic-βAla-Fpa-Tic-Oic-βAla-Dpr-Tic-Dpr-Dpr-Dpr-Dpr-AcetylationAmidationβAla = Beta alanine, Fpa = 4 Fluorophenyl alanine Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 100 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1762FKAB-1G2G-dF-Tic-Oic-GK-Tic-Oic-G-dF-Tic-Oic-GK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19MixHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1763FKAB-1G3GF-Tic-Oic-G-dK-Tic-Oic-GF-Tic-Oic-G-dK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19MixHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1764FKAB-1Go2G-Nph-Tic-Oic-GK-Tic-Oic-G-Nph-Tic-Oic-GK-Tic-KKKKAcetylationAmidationNph = 4-Nitrophneylalanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1765FKAB-1G-βAlaGF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-βAla-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, βAla = Beta alanineLinear20LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1766FKAB-1G-GabaGF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-Gaba-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Gaba = Gama aminobutyric acid Linear20LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 3 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1767FKAB-1G-AhxGF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-Ahx-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Ahx = 6-amino hexanoic acid Linear20LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1768FKAB-1GzGF-Tic-Oic-G-Dab-Tic-Oic-GF-Tic-Oic-G-Dab-Tic-Dab-Dab-Dab-DabAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Dab = 2,4-diaminobutanoic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1769FKAB-1G-ThiThi-GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKFreeAmidationThi = 2-Thienylalanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear20LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 30 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1770FKAB-1G-TrpGF-Tic-Oic-GW-Tic-Oic-GF-Tic-Oic-GW-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 100 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1771FKAB-1Gg2GF-Tic-Tic-GK-Tic-Tic-GF-Tic-Tic-GK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1772FKAB-1Go1G-Cph-Tic-Oic-GK-Tic-Oic-G-Cph-Tic-Oic-GK-Tic-KKKKAcetylationAmidationCph = 4-Chlorophenylalanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 10 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1773FKAB-1G1GF-Oic-Tic-GK-Oic-Tic-GF-Oic-Tic-GK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 30 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1774FKAB-1GvβAla-Fpa-Tic-Oic-βAla-K-Tic-Oic-βAla-Fpa-Tic-Oic-βAla-K-Tic-Dpr-Dpr-Dpr-DprAcetylationAmidationβAla = Beta alanine, Fpa = 4-Fluorophenylalanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 30 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1775FKAB-1GqKKKK-GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-TicAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LHydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranaeMIC = 3 μMBothNoneNAnot testedMice NANANANANoneAnti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis)2012US 2012/0197004
antitb_1778Peptide-22KL-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-Oic-KRFreeAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear21LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 30 µM or 93 µg/mLBothRBCNA63 % hemolytic activity at 100 µM peptidemouse skin wound healing model NAStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1779Peptide-23GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 10 µM or 24 µg/mLBothRBCNA14 % hemolytic activity at 100 µM peptidemouse skin wound healing model Acute toxicity was observed at dose of 125 mg/kgStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1780Peptide-24GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKAcetylationAddition of -CONH-CH2-CH2-NH2Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 10 µM or 25 µg/mLBothNANANot testedNA NAStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1781Peptide-25GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKAcetylationAddition of CONH-CH2-CH2-CH2-NH2Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 10 µM or 25 µg/mLBothNANANot testedNA NAStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1782Peptide-26GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKFreeAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 10 µM or 24 µg/mLBothRBCNA33.4 % and 14.3% hemolytic activity at 100 µM and 25 µM peptide respectivelyNA NAStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1783Peptide-27KL-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKKFreeAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 3 µM or 7.5 µg/mLBothRBCNA43.6 % and 24.9 % hemolytic activity at 100 µM and 25 µM peptide respectivelymouse skin wound healing model No toxicity observed at 25 mg/kg for 6 daysStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1784Peptide-28F-Tic-Oic-K-Tic-Oic-F-Tic-Oic-K-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear15LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 30 µM or 66 µg/mLBothRBCNA86.8 % and 50 % hemolytic activity at 100 µM and 25 µM peptide respectivelymouse skin wound healing model No toxicity observed at 25 mg/kg for 6 daysStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1785Peptide-29GABA-F-Tic-Oic-GABA-K-Tic-Oic-GABA-F-Tic-Oic-GABA-K-Tic-KKKKAcetylationAmidationGABA = Gama aminobutyric acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear19LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 10 µM or 28 µg/mLBothRBCNA10.8 % and 1 % hemolytic activity at 100 µM and 25 µM peptide respectivelymouse skin wound healing model No toxicity observed at 25 mg/kg for 6 daysStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1786Peptide-30G-Tic-Oic-K-Tic-Oic-G-Tic-Oic-K-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acidLinear15LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 3 µM or 6 µg/mLBothRBCNA26.7 % and 9.2 % hemolytic activity at 100 µM and 25 µM peptide respectivelymouse skin wound healing model No toxicity observed at 25 mg/kg for 6 daysStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1787Peptide-31GF-Oic-GK-Oic-GF-Oic-GKKKKKAcetylationAmidationOic = Octahydroindolecarboxylic acidLinear15LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 100 µM or 180 µg/mLBothRBCNA5.9 % and 3.2 % hemolytic activity at 100 µM and 25 µM peptide respectivelyNA NAStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385
antitb_1788Peptide-32GF-Tic-GK-Tic-GF-Tic-GK-Tic-KKKKAcetylationAmidationTic = tetrahydroisoquinolinecarboxylic acidLinear15LAmphipathic, HydrophobicSyntheticNAMycobacterium ranaeMycobacterium ranae (ATCC 110)MIC = 30 µM or 60 µg/mLBothRBCNA6 % and 4.9 % hemolytic activity at 100 µM and 25 µM peptide respectivelyNA NAStimulate innate immune systemNANANAAntibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223))200717547385