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Browse result page of AntiTbPdb

The total number entries retrieved from this search are 8
IDNameSequenceN-Terminal ModificationC-Terminal ModificationChemical ModificationLinear/CyclicLengthChiralityNatureSourceOriginSpeciesStrainInhibition ConcentrationIn vitro/ In vivoCell LineIntracellular InhibitionCytotoxicityAnimal ModelEffective Dose in model organismImmune ResponceMechanism of ActionTargetCombination TherapyOther ActivitiesYear of PublicationPubmed ID/ Patent No.
antitb_1195Boropentapeptide AVKAA-B(OH)2 FreeConjugated with Boronic acidConjugated with Boronic acidLinear5LNASyntheticNAMycobacterium thermoresistible Mycobacterium thermoresistible Poorer inhibition than Pinanediol PD-protected Boropentapeptide In vitroNoneNANANone NANAInhibit enzyme (MycP1) reponsible for cleavage of virulence factor (ESX secretion-associated protein B (EspB))Mycosin protease-1 (MycP1) NoneNone201424915878
antitb_1196Boropentapeptide AVKAA-B(OH)2 FreeConjugated with Boronic acidConjugated with Boronic acidLinear5LNASyntheticNAMycobacterium smegmatis Mycobacterium smegmatis Poorer inhibition than Pinanediol PD-protected Boropentapeptide In vitroNoneNANANone NANAInhibit enzyme (MycP1) reponsible for cleavage of virulence factor (ESX secretion-associated protein B (EspB))Mycosin protease-1 (MycP1) NoneNone201424915878
antitb_1197Boropentapeptide AVKAA-B(OH)2 FreeConjugated with Boronic acidConjugated with Boronic acidLinear5LNASyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis Poorer inhibition than Pinanediol PD-protected Boropentapeptide In vitroNoneNANANone NANAInhibit enzyme (MycP1) reponsible for cleavage of virulence factor (ESX secretion-associated protein B (EspB))Mycosin protease-1 (MycP1) NoneNone201424915878
antitb_1198Pinanediol PD-protected Boropentapeptide AVKAA-BO2(PD) FreeConjugated with Boronic acid and pinanediol PDConjugated with Boronic acid and pinanediol PDLinear5LNASyntheticNAMycobacterium thermoresistible Mycobacterium thermoresistible IC50 = 121.6 ± 25.3 μM for MycP1In vitroNoneNANANone NANAInhibit enzyme (MycP1) reponsible for cleavage of virulence factor (ESX secretion-associated protein B (EspB))Mycosin protease-1 (MycP1) NoneNone201424915878
antitb_1199Pinanediol PD-protected Boropentapeptide AVKAA-BO2(PD) FreeConjugated with Boronic acid and pinanediol PDConjugated with Boronic acid and pinanediol PDLinear5LNASyntheticNAMycobacterium smegmatis Mycobacterium smegmatis IC50 = 93.2±33.7 μM for MycP2In vitroNoneNANANone NANAInhibit enzyme (MycP1) reponsible for cleavage of virulence factor (ESX secretion-associated protein B (EspB))Mycosin protease-1 (MycP1) NoneNone201424915878
antitb_1200Pinanediol PD-protected Boropentapeptide AVKAA-BO2(PD) FreeConjugated with Boronic acid and pinanediol PDConjugated with Boronic acid and pinanediol PDLinear5LNASyntheticNAMycobacterium tuberculosis Mycobacterium tuberculosis IC50 = 37.9±5.2 μM for MycP3In vitroNoneNANANone NANAInhibit enzyme (MycP1) reponsible for cleavage of virulence factor (ESX secretion-associated protein B (EspB))Mycosin protease-1 (MycP1) NoneNone201424915878
antitb_1222PeptideSEFAYGSFVRTVSLPVConjugated with INHFreeConjugated with INH at N-terminalLinear16LNAProtein Derived91−106 region of the heat shock protein (Hsp16.3)NoneNoneNANANANANANA NANAInteract with Phospholipid Langmuir Monolayers and enhnaces the cell permating abiloity of INHPhospholipid Langmuir Monolayers Isoniazide (INH)None201323679078
antitb_1267L91SEFAYGSFVRTVSLPVGADEFreeFreeConjugated to TLR2-ligand Pam2CysLinear20LNAProtein DerivedFrom 16kDa antigenNoneNoneNAIn vivoNANANAFemale BALB/c mice (6-8 wk, 20±2 g) 20 nmolIt promotes the maturation of MHC-II and elicit secretion of IFN-Υ and also induce the expression of CD80, CD86 and CD40 co-stimulatory molecules and activate DCs to produce IL-6 and IL-12.NANANoneNA201324434326